Effects of lovastatin on the immune system

被引：26

作者：

Muldoon, MF

Flory, JD

Marsland, A

Manuck, SB

Whiteside, TL

Rabin, B

机构：

[1] UNIV PITTSBURGH, SCH MED, DEPT PATHOL, PITTSBURGH, PA 15260 USA

[2] UNIV PITTSBURGH, DEPT PSYCHOL, BEHAV PHYSIOL LAB, PITTSBURGH, PA 15260 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1997年 / 80卷 / 10期

关键词：

D O I：

10.1016/S0002-9149(97)00695-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Laboratory investigations have demonstrated that blockade of HMG-CoA reductase in vitro reduces lymphocyte proliferation in response to mitogens as well as other facets of the immune system, such as natural killer cell cytotoxicity. However, in this randomized and double-blind clinical investigation, treatment with 20-mg lovastatin for 6 months did not significantly alter several enumerative and functional characteristics of circulating immune cells.

引用

页码：1391 / +

页数：1

共 20 条

[1] CELLULAR-IMMUNITY IN DEPRESSED, CONDUCT DISORDER, AND NORMAL ADOLESCENTS - ROLE OF ADVERSE LIFE EVENTS [J].

BIRMAHER, B ;

RABIN, BS ;

GARCIA, MR ;

JAIN, U ;

WHITESIDE, TL ;

WILLIAMSON, DE ;

ALSHABBOUT, M ;

NELSON, BC ;

DAHL, RE ;

RYAN, ND .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1994, 33 (05) :671-678

[2]

CHAKRABARTI R, 1991, J BIOL CHEM, V266, P12216

[3]

CURTISS LK, 1995, NUTR MODULATION IMMU, P169

[4] SUPPRESSION OF LYMPHOID-CELL FUNCTION-INVITRO BY INHIBITION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE BY LOVASTATIN [J].

CUTTS, JL ;

BANKHURST, AD .

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1989, 11 (08) :863-869

[5] REVERSAL OF LOVASTATIN-MEDIATED INHIBITION OF NATURAL-KILLER-CELL CYTOTOXICITY BY INTERLEUKIN-2 [J].

CUTTS, JL ;

BANKHURST, AD .

JOURNAL OF CELLULAR PHYSIOLOGY, 1990, 145 (02) :244-252

[6]

GRUMLER J, 1994, BIOCHIM BIOPHYS ACTA, V1212, P259

[7] EFFECT OF PRAVASTATIN ON OUTCOMES AFTER CARDIAC TRANSPLANTATION [J].

KOBASHIGAWA, JA ;

KATZNELSON, S ;

LAKS, H ;

JOHNSON, JA ;

YEATMAN, L ;

WANG, XM ;

CHIA, D ;

TERASAKI, PI ;

SABAD, A ;

COGERT, GA ;

TROSIAN, K ;

HAMILTON, MA ;

MORIGUCHI, JD ;

KAWATA, N ;

HAGE, A ;

DRINKWATER, DC ;

STEVENSON, LW .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (10) :621-627

[8] LIPOPOLYSACCHARIDE-INDUCED NF-KAPPA-B ACTIVATION IN MOUSE 70Z/3 PRE-B LYMPHOCYTES IS INHIBITED BY MEVINOLIN AND 5'-METHYLTHIOADENOSINE - ROLES OF PROTEIN ISOPRENYLATION AND CARBOXYL METHYLATION REACTIONS [J].

LAW, RE ;

STIMMEL, JB ;

DAMORE, MA ;

CARTER, C ;

CLARKE, S ;

WALL, R .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (01) :103-111

[9]

LEWIS DE, 1992, MANUAL CLIN LABORATO, P164

[10]

LINNA J, 1991, ADV EXP MED BIOL, V288, P269

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