Effects of lovastatin on the immune system

被引：26

作者：

Muldoon, MF

Flory, JD

Marsland, A

Manuck, SB

Whiteside, TL

Rabin, B

机构：

[1] UNIV PITTSBURGH, SCH MED, DEPT PATHOL, PITTSBURGH, PA 15260 USA

[2] UNIV PITTSBURGH, DEPT PSYCHOL, BEHAV PHYSIOL LAB, PITTSBURGH, PA 15260 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1997年 / 80卷 / 10期

关键词：

D O I：

10.1016/S0002-9149(97)00695-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Laboratory investigations have demonstrated that blockade of HMG-CoA reductase in vitro reduces lymphocyte proliferation in response to mitogens as well as other facets of the immune system, such as natural killer cell cytotoxicity. However, in this randomized and double-blind clinical investigation, treatment with 20-mg lovastatin for 6 months did not significantly alter several enumerative and functional characteristics of circulating immune cells.

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收藏

页码：1391 / +

页数：1

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