Uric acid promotes tumor immune rejection

被引:97
作者
Hu, DE
Moore, AM
Thomsen, LL
Brindle, KM
机构
[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
[2] GlaxoSmithKline, Immunotherapeut Dept, Immunomodulat Sect, Stevenage, Herts, England
关键词
D O I
10.1158/0008-5472.CAN-04-1586
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Uric acid released from dying cells has been shown recently to act as a danger signal for the immune system, stimulating dendritic cell maturation and enhancing T-cell responses to foreign antigens. Stimulation of dendritic cell maturation by uric acid has been proposed as a mechanism by which the immune system could generate responses against tumors. We show here that uric acid levels are elevated in tumors undergoing immune rejection and that the inhibition of uric acid production, by systemic administration of allopurinol, or the removal of uric acid, by administration of uricase, delayed tumor immune rejection, whereas subcutaneous administration of crystalline uric acid enhanced the rejection process.
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页码:5059 / 5062
页数:4
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