No Ghrelin Response to Oral Glucose in Diabetes Mellitus with Gastroparesis

被引：13

作者：

Asai, Shiko ^{[1
]}

Katabami, Takuyuki ^{[1
]}

Obi, Naoko ^{[1
]}

Matsui, Tomoya ^{[1
]}

Kato, Hiroyuki ^{[1
]}

Obi, Ryusei ^{[1
]}

Ogawa, Yutaka ^{[1
]}

Kawata, Takehiro ^{[1
]}

Takama, Haruyuki ^{[1
]}

Ohta, Akio ^{[1
]}

Tanaka, Yasushi ^{[1
]}

机构：

[1] St Marianna Univ, Sch Med, Div Endocrinol & Metab, Dept Internal Med,Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan

来源：

ENDOCRINE JOURNAL | 2009年 / 56卷 / 01期

关键词：

Ghrelin; Diabetic gastroparesis; Cardiac autonomic neuropathy; C-13-acetate breath test; Coefficient of variation of the R-R interval; GASTRIC-EMPTYING RATE; GASTROINTESTINAL SYMPTOMS; CIRCULATING GHRELIN; DOUBLE-BLIND; PLASMA; SECRETION; HORMONE; INSULIN; SUPPRESSION; CROSSOVER;

D O I：

10.1507/endocrj.K08E-169

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

To investigate the role of ghrelin, all endogenous ligand of the growth hormone secretagogue receptor, in diabetic gastroparesis, we evaluated the plasma ghrelin profile during the oral glucose tolerance test in 55 patients with diabetes (men/women: 36/19, mean +/- SE of age: 55.1 +/- 1.7 years) with or without gastroparesis (diagnosed by the C-13-acetate breath test). We also further examined cardiac autonomic neuropathy by assessing 24-hour variation of the R-R interval in randomly selected 32 patients with diabetes (men/women: 23/9, mean +/- SE of age: 54.2 +/- 2.5 years), and evaluated the influence of autonomic neuropathy on ghrelin. The fasting plasma ghrelin level was significantly lower in diabetes mellitus With gastroparesis than in healthy controls (7.9 +/- 0.7 fmol/ml versus 16.6 +/- 5.3 fmol/ml, p=0.006). Patients with diabetes with gastroparesis showed no decrease of plasma ghrelin after glucose loading, unlike patients without gastroparesis or healthy controls. Diabetes mellitus with autonomic neuropathy, but not those without it, also showed no decrease of plasma ghrelin after glucose loading. Diabetic gastroparesis may be related to ghrelin-associated neurohormonal abnormalities, but the pathophysiological meaning of this abnormal ghrelin response needs further clarification.

引用

页码：79 / 87

页数：9

共 36 条

[1]

Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-1 levels and bowel movement frequency and negatively with systolic blood pressure [J].