Genetic susceptibility to tuberculosis

被引：17

作者：

Malik, S ^{[1
]}

Schurr, E ^{[1
]}

机构：

[1] McGill Univ, McGill Ctr Study Host Resistance, Montreal, PQ, Canada

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2002年 / 40卷 / 09期

关键词：

tuberculosis; host genetics; gene polymorphism; natural resistance associated macrophage protein 1(NRAMP1); vitamin D receptor : VDR; human leukocyte antigen : HLA;

D O I：

10.1515/CCLM.2002.153

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Tuberculosis, caused by the human pathogen Mycobacterium tuberculosis (M. tuberculosis), affects an estimated 8 million people annually, resulting in approximately 2 million deaths. Human genetic variability is an important modulator of tuberculosis susceptibility. This review will discuss candidate susceptibility genes that have been implicated in tuberculosis susceptibility across various ethnic groups and epidemiological settings. Evaluating the genetic variants of tuberculosis susceptibility genes will provide us with a better understanding of the disease mechanisms in tuberculosis. Ultimately, such genetic studies may lead to the development of effective alternative treatments to cope with the growing problem of tuberculosis infections due to the AIDS pandemic, the emergence of multidrug resistant M. tuberculosis, and the limited efficacy of Mycobacterium bovis (BCG) vaccination.

引用

页码：863 / 868

页数：6

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