Improvement of the synthesis of chiral non-racemic bicyclic lactams in the piperidin-2-ones series.

被引：21

作者：

Micouin, L ^{[1
]}

Quirion, JC ^{[1
]}

Husson, HP ^{[1
]}

机构：

[1] UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,CNRS,CHIM THERAPEUT LAB,F-75270 PARIS 06,FRANCE

来源：

SYNTHETIC COMMUNICATIONS | 1996年 / 26卷 / 08期

关键词：

D O I：

10.1080/00397919608003529

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bicyclic lactams 8 have been prepared in enantiomerically pure form from the corresponding amino esters 5 and glutaric anhydride. The key step is the reduction of imides 7 in methanol. Selective reduction of 8 furnished N-substituted lactams 9.

引用

页码：1605 / 1611

页数：7

共 8 条

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