Design of aging intervention studies: the NIA interventions testing program

被引：111

作者：

Nadon, N. L. ^{[1
]}

Strong, R. ^{[2
,4
,11
]}

Miller, R. A. ^{[5
,6
,7
]}

Nelson, J. ^{[3
,4
]}

Javors, M. ^{[8
]}

Sharp, Z. D. ^{[9
]}

Peralba, J. M. ^{[9
]}

Harrison, D. E. ^{[10
]}

机构：

[1] NIA, Biol Aging Program, Bethesda, MD 20892 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA

[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA

[4] Univ Texas Hlth Sci Ctr San Antonio, Barshop Aging Inst, San Antonio, TX 78229 USA

[5] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[6] Univ Michigan, Geriatr Ctr, Ann Arbor, MI 48109 USA

[7] VA Med Ctr, Ann Arbor, MI USA

[8] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA

[9] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, San Antonio, TX 78229 USA

[10] Jackson Labs, Bar Harbor, ME USA

[11] S Texas Vet Hlth Care Syst, San Antonio, TX USA

来源：

AGE | 2008年 / 30卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Anti-aging; Lifespan; Longevity; Mice;

D O I：

10.1007/s11357-008-9048-1

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 [法学]; 0303 [社会学]; 100203 [老年医学];

摘要：

The field of biogerontology has made great strides towards understanding the biological processes underlying aging, and the time is ripe to look towards applying this knowledge to the pursuit of aging interventions. Identification of safe, inexpensive, and non-invasive interventions that slow the aging process and promote healthy aging could have a significant impact on quality of life and health care expenditures for the aged. While there is a plethora of supplements and interventions on the market that purport to slow aging, the evidence to validate such claims is generally lacking. Here we describe the development of an aging interventions testing program funded by the National Institute on Aging (NIA) to test candidate interventions in a model system. The development of this program highlights the challenges of long-term intervention studies and provides approaches to cope with the stringent requirements of a multi-site testing program.

引用

页码：187 / 199

页数：13

共 82 条

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