Is early life body weight a predictor of longevity and tumor risk in rats?

被引：10

作者：

Anisimov, VN

Arbeev, KG

Popovich, IG

Zabezhinksi, MA

Arbeeva, LS

Yashin, AI

机构：

[1] NN Petrov Oncol Res Inst, Dept Carcinogenesis & Oncogerontol, St Petersburg 197758, Russia

[2] Max Planck Inst Demog Res, D-18057 Rostock, Germany

来源：

EXPERIMENTAL GERONTOLOGY | 2004年 / 39卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

body weight; longevity; cancer risk; rat;

D O I：

10.1016/j.exger.2004.02.004

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Heavy body weight (BW) is thought to be associated with reduced longevity and age-associated diseases, including cancer, both in laboratory rodents and humans. To further investigate the interactions between BW, longevity and spontaneous tumor development, we measured the correlations between BW in early life, BW in middle life, and parameters of life span and tumorigenesis in male and female outbred rats. The data show that BW at the ages of both 3 and 12 months are significant predictors of longevity in rats. Heavier female rats tend to live longer than the lighter female rats, while in male those who were light at 3 months but heavy at 12 month had the best longevity. BW at the age 3 months was not predictive of tumor growth but being heavier at the age of I year did confer an increased risk of tumor development for both male and female rats. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：807 / 816

页数：10

共 54 条

[51]

Weindruch R., 1988, RETARDATION AGING DI

[52]

Weisberg S., 1980, APPL LINEAR REGRESSI

[53] Longevity and aging of mice from lines divergently selected for body weight for over 90 generations [J].