Natural products and drug discovery Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?

被引：417

作者：

Ji, Hong-Fang ^{[1
]}

Li, Xue-Juan ^{[1
]}

Zhang, Hong-Yu ^{[1
]}

机构：

[1] Shandong Univ Technol, Shandong Prov Res Ctr Bioinformat Engn & Tech, Zibo, Peoples R China

来源：

EMBO REPORTS | 2009年 / 10卷 / 03期

关键词：

THERAPEUTICS; MEDICINES; EVOLUTION; SYNERGY; AGENTS; PLANTS;

D O I：

10.1038/embor.2009.12

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：194 / 200

页数：7

共 46 条

[21] Harnessing Nature's wisdom - Turning to Nature for inspiration and avoiding her follies [J].

Hunter, Philip .

EMBO REPORTS, 2008, 9 (09) :838-840

[22] Multipotent natural agents to combat Alzheimer's disease. Functional spectrum and structural features [J].

Ji, Hong-fang ;

Zhang, Hong-yu .

ACTA PHARMACOLOGICA SINICA, 2008, 29 (02) :143-151

[23] Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery [J].

Ji, Hong-Fang ;

Kong, De-Xin ;

Shen, Liang ;

Chen, Ling-Ling ;

Ma, Bin-Guang ;

Zhang, Hong-Yu .

GENOME BIOLOGY, 2007, 8 (08)

[24]

Jiao Y.M., 2005, J. TCM, V36, P58

[25] The impact of Arabidopsis on human health:: Diversifying our portfolio [J].

Jones, Alan M. ;

Chory, Joanne ;

Dangl, Jeffery L. ;

Estelle, Mark ;

Jacobsen, Steven E. ;

Meyerowitz, Elliot M. ;

Nordborg, Magnus ;

Weigel, Detlef .

CELL, 2008, 133 (06) :939-943

[26] Multicomponent therapeutics for networked systems [J].

Keith, CT ;

Borisy, AA ;

Stockwell, BR .

NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (01) :71-U10

[27] The evolving role of natural products in drug discovery [J].

Koehn, FE ;

Carter, GT .

NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (03) :206-220

[28] Convergent evolution of medicines [J].

Kong, De-Xin ;

Li, Xue-Juan ;

Zhang, Hong-Yu .

CHEMMEDCHEM, 2008, 3 (08) :1169-1171

[29] How many traditional Chinese medicine components have been recognized by modern Western medicine? A chemoinformatic analysis and implications for finding multicomponent drugs [J].

Kong, De-Xin ;

Li, Xue-Juan ;

Tang, Guang-Yan ;

Zhang, Hong-Yu .

CHEMMEDCHEM, 2008, 3 (02) :233-236

[30] Where is the hope for drug discovery? Let history tell the future [J].

Kong, De-Xin ;

Li, Xue-Juan ;

Zhang, Hong-Yu .

DRUG DISCOVERY TODAY, 2009, 14 (3-4) :115-119

← 1 2 3 4 5 →