Effects of additives on the growth of L-glutamic acid crystals (beta-form)

被引:19
作者
Sano, C [1 ]
Kashiwagi, T [1 ]
Nagashima, N [1 ]
Kawakita, T [1 ]
机构
[1] AJINOMOTO CO INC, CENT RES LABS, KAWASAKI KU, KAWASAKI, KANAGAWA 210, JAPAN
关键词
L-glutamic acid; polymorph; transformation; tailor-made additives; amino acid;
D O I
10.1016/S0022-0248(97)00013-4
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
To elucidate the mechanism of polymorph-selective crystallization of L-glutamic acid (L-Glu) crystals by the additives, the effects of various L-amino acids, carboxylic acids, and a di-peptide, gamma-L-glutamyl-L-glutamic acid (gamma-Glu-Glu) on the growth of the {1 0 1}, {0 1 0}, and {0 0 1}, three dominant faces of the beta-form of L-Glu crystals have been investigated experimentally and structurally. gamma-Glu-Glu and L-phenylalanine (L-Phe) showed nearly the same strong inhibitory effects on the three faces of the P-form in contrast to their different behavior on the two dominant faces of the alpha-form of L-Glu. These phenomena were explained in terms of the characteristics of the hydrogen bonds of each face and it was found that the beta-form has less discriminating capacity than the alpha-form for the recognition of the molecules. Finally, the cause of the polymorph-selective crystallization by the additives in the L-Glu is attributed mainly to the difference in the inhibitory effects of the additives on the two dominant faces of the alpha-form.
引用
收藏
页码:568 / 574
页数:7
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