共 63 条
Induced reactivity of intestinal CD4+ T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation
被引:124
作者:

Hokama, A
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机构: Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

Mizoguchi, E
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机构: Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

Sugimoto, K
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机构: Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

Shimomura, Y
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机构: Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

Tanaka, Y
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机构: Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

Yoshida, M
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机构: Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

Rietdijk, ST
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机构: Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

de Jong, YP
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机构: Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

Snapper, SB
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机构: Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

Terhorst, C
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机构: Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

Blumberg, RS
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机构: Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

Mizoguchi, A
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机构:
Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
机构:
[1] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Ctr Study Inflammat Bowel Dis, Boston, MA 02114 USA
[4] Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA
[5] Beth Israel Deaconess Med Ctr, Div Immunol, Boston, MA USA
[6] Harvard Univ, Sch Med, Dept Pathol & Med, Boston, MA USA
来源:
关键词:
D O I:
10.1016/j.immuni.2004.05.009
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Inflammatory bowel disease is an immune-mediated intestinal inflammatory condition that is associated with an increase in autoantibodies that bind to epithelial cells. However, it is unknown whether the epithelial cell-derived products that are recognized by such autoantibodies are involved in the pathogenic process. Through a combined antigen-screening approach utilizing humoral and cellular immune responses, we identify herein an epithelial lectin, galectin-4, that specifically stimulates IL-6 production by CD4(+) T cells. Interestingly, the reactivity of CD4(+) T cells to galectin-4 is precisely elicited under intestinal inflammatory conditions. The galectin-4-mediated production of IL-6 is MHC class II independent and induced by PKCtheta-associated pathway through the immunological synapse. The galectin-4-mediated stimulation of CD4(+) T cells is shown to exacerbate chronic colitis and delay the recovery from acute intestinal injury. These studies identify the presence of an immunogenic, endogenous lectin in the intestine and dissect the biological role of lectin/CD4(+) T cell interactions under inflammatory conditions.
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页码:681 / 693
页数:13
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