Syntheses of 2-alkylamino- and 2-dialkylamino-4,6-diarylpyridines and 2,4,6-trisubstituted pyrimidines using solid-phase-bound chalcones

被引：29

作者：

Katritzky, AR ^{[1
]}

Serdyuk, L

Chassaing, C

Toader, D

Wang, XJ

Forood, B

Flatt, B

Sun, CC

Vo, K

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

[2] Trega Biosci Inc, Exploratory Chem, San Diego, CA 92121 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2000年 / 2卷 / 02期

关键词：

D O I：

10.1021/cc990072q

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Several substituted 2- and 4-hydroxyacetophenones are linked to Wang resin via a modified Mitsunobu protocol. These resin-bound acetophenones are condensed with aromatic aldehydes, and the resulting chalcones 5 are used for the synthesis of 2-dialkylamino- (9a-d) and 2-alkylamino-4,6-diarylpyridines (11a-f), and 2-alkyl-4,6-diaryl- (14a) and 2,4,6-triarylpyrimidines (14b,c) in a manner suitable for combinatorial applications.

引用

页码：182 / 185

页数：4

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