System-wide molecular evidence for phenotypic buffering in Arabidopsis

被引：181

作者：

Fu, Jingyuan ^{[1
,2
]}

Keurentjes, Joost J. B. ^{[3
,4
,5
]}

Bouwmeester, Harro ^{[4
,5
,6
]}

America, Twan ^{[5
,6
]}

Verstappen, Francel W. A. ^{[4
,5
,6
]}

Ward, Jane L. ^{[7
]}

Beale, Michael H. ^{[7
]}

de Vos, Ric C. H. ^{[5
,6
]}

Dijkstra, Martijn ^{[1
]}

Scheltema, Richard A. ^{[1
]}

Johannes, Frank ^{[1
]}

Koornneef, Maarten ^{[3
,8
]}

Vreugdenhil, Dick ^{[4
]}

Breitling, Rainer ^{[1
]}

Jansen, Ritsert C. ^{[1
,2
]}

机构：

[1] Univ Groningen, Groningen Bioinformat Ctr, NL-9751 NN Haren, Netherlands

[2] Univ Groningen, Dept Genet, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands

[3] Wageningen Univ, Genet Lab, NL-6703 BD Wageningen, Netherlands

[4] Wageningen Univ, Lab Plant Physiol, NL-6703 BD Wageningen, Netherlands

[5] Ctr Biosyst Genom, NL-6708 PB Wageningen, Netherlands

[6] Plant Res Int, NL-6708 PB Wageningen, Netherlands

[7] Natl Ctr Plant & Microbial Metab, Harpenden AL5 2JQ, Herts, England

[8] Max Planck Inst Plant Breeding Res, D-50829 Cologne, Germany

来源：

NATURE GENETICS | 2009年 / 41卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

GENETIC GENOMICS; EXPRESSION;

D O I：

10.1038/ng.308

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We profiled 162 lines of Arabidopsis for variation in transcript, protein and metabolite abundance using mRNA microarrays, two-dimensional polyacrylamide gel electrophoresis, gas chromatography time-of-flight mass spectrometry, liquid chromatography quadrupole time-of-flight mass spectrometry, and proton nuclear magnetic resonance. We added all publicly available phenotypic data from the same lines and mapped quantitative trait loci (QTL) for 40,580 molecular and 139 phenotypic traits. We found six QTL hot spots with major, system-wide effects, suggesting there are six breakpoints in a system otherwise buffered against many of the 500,000 SNPs.

引用

页码：166 / 167

页数：2

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