Drug discovery:: Here comes the worm

被引：20

作者：

Segalat, Laurent ^{[1
]}

机构：

[1] Univ Lyon, CNRS, UMR 5534, Lyon, France

来源：

ACS CHEMICAL BIOLOGY | 2006年 / 1卷 / 05期

关键词：

D O I：

10.1021/cb600221m

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Identification of bioactive molecules and their targets impedes the process of drug development. In a recent paper, a genetically tractable organism, the Caenorhabditis elegans worm, is shown to be a viable screening system in which the drug target and the pathway it activates can be readily identified.

引用

页码：277 / 278

页数：2

共 4 条

[1]

GAUD A, 2004, NEUROMUSCLAR DISORD, V4, P365

[2] A small-molecule screen in C-elegans yields a new calcium channel antagonist [J].