Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages

被引：136

作者：

Matsuda, H ^{[1
]}

Kageura, T ^{[1
]}

Morikawa, T ^{[1
]}

Toguchida, I ^{[1
]}

Harima, S ^{[1
]}

Yoshikawa, M ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078414, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(99)00702-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new anthraquinone glucosides [chrysophanol 8-O-beta-D-(6'-galloyl)-glucopyranoside, aloe-emodin 1-O-beta-D-glucopyranoside] together with various known stilbenes and their glucosides, anthraquinone glucosides, and a naphthalene glucoside were isolated from the rhizome of Rheum undulatum L. Three stilbenes (rhapontigenin, piceatannol, resveratrol), a naphthalene glucoside (torachrysone 8-O-beta-D-glucopyranoside), and two stilbene glucoside gallates (rhaponticin 2 "-O-gallate, rhaponticin 6 "-O-gallate) showed inhibitory activity of NO production in lipopolysaccharide-activated macrophages. (IC50 = 11-69 mu M). The oxygen Functions (-OH,-OCH3) at the benzene ring were found to be essential to show the activity. Whereas, the glucoside moiety reduced the activity, while the alpha,beta-double bond did not affect the activity. Furthermore; the active stilbenes (rhapontigenin, piceatannol, resveratrol) inhibited iNOS induction. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：323 / 327

页数：5

共 14 条

[1] NEW NATURAL STILBENE GLUCOSIDE FROM RHEUM-RHAPONTICUM (POLYGONACEAE) [J].