Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages

被引:136
作者
Matsuda, H [1 ]
Kageura, T [1 ]
Morikawa, T [1 ]
Toguchida, I [1 ]
Harima, S [1 ]
Yoshikawa, M [1 ]
机构
[1] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078414, Japan
关键词
D O I
10.1016/S0960-894X(99)00702-7
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Two new anthraquinone glucosides [chrysophanol 8-O-beta-D-(6'-galloyl)-glucopyranoside, aloe-emodin 1-O-beta-D-glucopyranoside] together with various known stilbenes and their glucosides, anthraquinone glucosides, and a naphthalene glucoside were isolated from the rhizome of Rheum undulatum L. Three stilbenes (rhapontigenin, piceatannol, resveratrol), a naphthalene glucoside (torachrysone 8-O-beta-D-glucopyranoside), and two stilbene glucoside gallates (rhaponticin 2 "-O-gallate, rhaponticin 6 "-O-gallate) showed inhibitory activity of NO production in lipopolysaccharide-activated macrophages. (IC50 = 11-69 mu M). The oxygen Functions (-OH,-OCH3) at the benzene ring were found to be essential to show the activity. Whereas, the glucoside moiety reduced the activity, while the alpha,beta-double bond did not affect the activity. Furthermore; the active stilbenes (rhapontigenin, piceatannol, resveratrol) inhibited iNOS induction. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:323 / 327
页数:5
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