Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles

被引：531

作者：

Dobrovolskaia, Marina A. ^{[1
]}

Patri, Anil K. ^{[1
]}

Zheng, Jiwen ^{[1
]}

Clogston, Jeffrey D. ^{[1
]}

Ayub, Nader ^{[1
]}

Aggarwal, Parag ^{[1
]}

Neun, Barry W. ^{[1
]}

Hall, Jennifer B. ^{[1
]}

McNeil, Scott E. ^{[1
]}

机构：

[1] SAIC Frederick Inc, Nanotechnol Characterizat Lab, Adv Technol Program, NCI Frederick, Frederick, MD 21702 USA

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2009年 / 5卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Nanoparticles; Gold colloids; Plasma protein binding; Hydrodynamic size; Complement; ENHANCED RAMAN-SCATTERING; PEG-CHAIN-LENGTH; 2-DIMENSIONAL ELECTROPHORESIS; REJECTING PROPERTIES; SURFACE-DENSITY; DRUG-DELIVERY; ADSORPTION; IDENTIFICATION;

D O I：

10.1016/j.nano.2008.08.001

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Nanoparticle size and plasma binding profile contribute to a particle's longevity in the bloodstream, which can have important consequences for therapeutic efficacy. In this study an approximate doubling in nanoparticle hydrodynamic size was observed upon in vitro incubation of 30- and 50-nm colloidal gold in human plasma. Plasma proteins that bind the surface of citrate-stabilized gold colloids have been identified. Effects of protein binding on the nanoparticle hydrodynamic size, elements of coagulation, and the complement system have been investigated. The difference in size measurements obtained from dynamic light scattering, electron microscopy, and scanning probe microscopy are also discussed. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：106 / 117

页数：12

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