Catheter-tip colonization as a surrogate end point in clinical studies on catheter-related bloodstream infection: How strong is the evidence?

被引：106

作者：

Rijnders, BJA ^{[1
]}

Van Wijngaerden, E ^{[1
]}

Peetermans, WE ^{[1
]}

机构：

[1] Univ Ziekenhuizen Leuven, Dept Internal Med & Infect Dis, B-3000 Louvain, Belgium

来源：

CLINICAL INFECTIOUS DISEASES | 2002年 / 35卷 / 09期

关键词：

D O I：

10.1086/342905

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In clinical trials, the incidence of catheter-tip colonization (CTC) is frequently used as a surrogate end point for the incidence of catheter-related bloodstream infection (BSI). It is not clear whether the correlation between CTC and catheter-related BSI is good. We searched the MEDLINE database and conducted a literature search for the years 1990-2002 and retrieved 29 studies (with a total of 60 study groups) with incidence data on predefined CTC and catheter-related BSI definitions. A good linear correlation between CTC and catheter-related BSI was found (r = 0.69; r(2) = 0.48; P < .001). The data from the medical literature about catheter-related infection seem to support the use of CTC as a surrogate end point for catheter-related BSI. In evaluations of clinical interventions or new techniques for the prevention of catheter-related BSI, investigation of the prevention of CTC seems to be a logical first step.

引用

页码：1053 / 1058

页数：6

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