Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration

被引：139

作者：

Spielman, Lindsay J. ^{[1
]}

Little, Jonathan P. ^{[2
]}

Klegeris, Andis ^{[1
]}

机构：

[1] Univ British Columbia, Dept Biol, Kelowna, BC V1V 1V7, Canada

[2] Univ British Columbia, Sch Hlth & Exercise Sci, Kelowna, BC V1V 1V7, Canada

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 273卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Adipose tissue; Cytokines; Neuroinflammation; Alzheimer's disease; Parkinson's disease; Huntington's disease; GROWTH-FACTOR-I; CENTRAL-NERVOUS-SYSTEM; TUMOR-NECROSIS-FACTOR; BODY-MASS INDEX; PROTEIN-KINASE B/AKT; BLOOD-BRAIN-BARRIER; HIGH-FAT DIET; NF-KAPPA-B; ALZHEIMERS-DISEASE; HUNTINGTONS-DISEASE;

D O I：

10.1016/j.jneuroim.2014.06.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Obesity is a growing epidemic that contributes to several brain disorders including Alzheimer's, Parkinson's, and Huntington's diseases. Obesity could promote these diseases through several different mechanisms. Here we review evidence supporting the involvement of two recently recognized factors linking obesity with neurodegeneration: the induction of pro-inflammatory cytokines and onset of insulin and insulin-like growth factor 1 (IGF-1) resistance. Excess peripheral pro-inflammatory mediators, some of which can cross the blood brain barrier, may trigger neuroinflammation, which subsequently exacerbates neurodegeneration. Insulin and IGF-1 resistance leads to weakening of neuroprotective signaling by these molecules and can contribute to onset of neurodegenerative diseases. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：8 / 21

页数：14

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