Antagomirzymes: Oligonucleotide Enzymes That Specifically Silence MicroRNA Function

被引：51

作者：

Jadhav, Vaibhav M. ^{[1
]}

Scaria, Vinod ^{[1
]}

Maiti, Souvik ^{[1
]}

机构：

[1] Inst Genom & Integrat Biol, CSIR, Delhi 110007, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 14期

关键词：

DNAzymes; locked nucleic acids; microRNA; nucleic acid enzymes; synthetic biology; IN-VIVO; THERAPEUTIC APPLICATIONS; GENE-REGULATION; RNA CLEAVAGE; DNAZYMES; LNA; DISEASE; MIRNAS; WORLD; VITRO;

D O I：

10.1002/anie.200805521

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Many important cellular processes are regulated by small endogenous noncoding RNAs known as microRNAs (miRNAs). The precise molecular function of many miRNAs is unknown; different loss-of-function methods are required to gain insight into the biology of these small RNA molecules. Nucleic acid enzymes termed antagomirzymes are now shown to be valuable tools for the specific knockdown of miRNA in vitro and in vivo (see scheme). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2557 / 2560

页数：4

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