Drug discovery from natural sources

被引:444
作者
Chin, Young-Won
Balunas, Marcy J.
Chai, Hee Byung
Kinghorn, A. Douglas [1 ]
机构
[1] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA
[2] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA
[3] Univ Illinois, Coll Pharm, Dept Med Chem, Chicago, IL 60612 USA
[4] Univ Illinois, Coll Pharm, Dept Pharmacognosy, Chicago, IL 60612 USA
关键词
natural products; drug discovery; terrestrial plants; terrestrial microorganisms; marine organisms; terrestrial vertebrates; terrestrial invertebrates; chemical diversity;
D O I
10.1007/BF02854894
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Organic compounds from terrestrial and marine organisms have extensive past and present use in the treatment of many diseases and serve as compounds of interest both in their natural form and as templates for synthetic modification. Over 20 new drugs launched on the market between 2000 and 2005, originating from terrestrial plants, terrestrial microorganisms, marine organisms, and terrestrial vertebrates and invertebrates, are described. These approved substances, representative of very wide chemical diversity, together with several other natural products or their analogs undergoing clinical trials, continue to demonstrate the importance of compounds from natural sources in modern drug discovery efforts.
引用
收藏
页码:E239 / E253
页数:15
相关论文
共 128 条
[31]   Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia [J].
Giles, F ;
Estey, E ;
O'Brien, S .
CANCER, 2003, 98 (10) :2095-2104
[32]   Bivalirudin: A direct thrombin inhibitor [J].
Gladwell, TD .
CLINICAL THERAPEUTICS, 2002, 24 (01) :38-58
[33]   Epothilones: Mechanism of action and biologic activity [J].
Goodin, S ;
Kane, MP ;
Rubin, EH .
JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (10) :2015-2025
[34]  
GRIFO F, 1997, BIODIVERSITY HUMAN H, P131
[35]   Pimecrolimus: A review [J].
Gupta, AK ;
Chow, M .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2003, 17 (05) :493-503
[36]   Drugs from the deep: marine natural products as drug candidates [J].
Haefner, B .
DRUG DISCOVERY TODAY, 2003, 8 (12) :536-544
[37]   Pharmacokinetics and pharmacodynamics of NTBC (2-(2-nitro-4-fluoromethylbenzoyl)-1,3-cyclohexanedione) and mesotrione, inhibitors of 4-hydroxyphenyl pyruvate dioxygenase (HPPD) following a single dose to healthy male volunteers [J].
Hall, MG ;
Wilks, MF ;
Provan, WM ;
Eksborg, S ;
Lumholtz, B .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2001, 52 (02) :169-177
[38]  
Hao D, 2003, CLIN CANCER RES, V9, P2465
[39]   α-galactosylceramide (KRN7000) suppression of chernical- and oncogene-dependent carcinogenesis [J].
Hayakawa, Y ;
Rovero, S ;
Forni, G ;
Smyth, MJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (16) :9464-9469
[40]   Galanthamine from snowdrop - the development of a modern drug against Alzheimer's disease from local Caucasian knowledge [J].
Heinrich, M ;
Teoh, HL .
JOURNAL OF ETHNOPHARMACOLOGY, 2004, 92 (2-3) :147-162