Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells

被引：72

作者：

Oh, H

Lee, HS

Kim, T

Chai, KY

Chung, HT

Kwon, TO

Jun, JY

Jeong, OS

Kim, YC

Yun, YG ^{[1
]}

机构：

[1] Wonkwang Univ, Med Resources Res Ctr, Iksan 570749, Chonbuk, South Korea

[2] Wonkwang Univ, Grad Sch Oriental Med, Iksan 570749, Chonbuk, South Korea

[3] Wonkwang Univ, MRRC, Iksan 570749, Chonbuk, South Korea

[4] Wonkwang Univ, Coll Pharm, Iksan 570749, Chonbuk, South Korea

来源：

PLANTA MEDICA | 2002年 / 68卷 / 05期

关键词：

D O I：

10.1055/s-2002-32075

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Fractionation of the MeOH extract of Angelica dahurica Benth et Hook resulted in the isolation of six furocoumarins, imperatorin (1), isoimperatorin (2), (+/-)-byakangelicol (3), (+)-oxypeucedanin (4), (+)-byakangelicin (5), and (+)-aviprin (6). Among these, compounds 1 and 5 exhibited strong hepatoprotective activities, displaying EC50 values of 36.6+/-0.98 and 47.9+/-4.6 muM, respectively. Compounds 3 and 4 showed moderate activities with EC50 values of 112.7+/-5.35 and 286.7+/-6.36 muM, respectively. Silybin as a positive control showed the EC50 value with 69.0+/-3.4 muM. Comparison of hepatoprotective activities for six furocournarins 1-6 suggested that oxy-substitution at the C-9 position increased the hepatoprotective activity.

引用

页码：463 / 464

页数：2