Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels

被引：212

作者：

Hartzell, H. Criss ^{[1
]}

Yu, Kuai ^{[1
]}

Xiao, Qinhuan ^{[1
]}

Chien, Li-Ting ^{[1
]}

Qu, Zhiqiang ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Cell Biol, Atlanta, GA 30322 USA

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2009年 / 587卷 / 10期

关键词：

SMOOTH-MUSCLE-CELLS; ACTIVATED CHLORIDE CHANNELS; GASTROINTESTINAL STROMAL TUMORS; PLASMA-MEMBRANE PROTEIN; XENOPUS-LAEVIS OOCYTES; SACCHAROMYCES-CEREVISIAE; GNATHODIAPHYSEAL-DYSPLASIA; TRANSCRIPTOME ANALYSIS; TRANSMEMBRANE PROTEIN; INTRACELLULAR CALCIUM;

D O I：

10.1113/jphysiol.2008.163709

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Ca2+-activated Cl- channels (CaCCs) perform many important functions in cell physiology including secretion of fluids from acinar cells of secretory glands, amplification of olfactory transduction, regulation of cardiac and neuronal excitability, mediation of the fast block to polyspermy in amphibian oocytes, and regulation of vascular tone. Although a number of proteins have been proposed to be responsible for CaCC currents, the anoctamin family (ANO, also known as TMEM16) exhibits characteristics most similar to those expected for the classical CaCC. Interestingly, this family of proteins has previously attracted the interest of both developmental and cancer biologists. Some members of this family are up-regulated in a number of tumours and functional deficiency in others is linked to developmental defects.

引用

页码：2127 / 2139

页数：13

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