Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape

被引：179

作者：

Agace, William W. ^{[1
,2
]}

McCoy, Kathy D. ^{[3
]}

机构：

[1] Tech Univ Denmark DTU, Natl Vet Inst, Div Immunol & Vaccinol, DK-2800 Lyngby, Denmark

[2] Lund Univ, Immunol Sect, Dept Expt Med Sci, BMC D14,Solvegatan 19, S-22184 Lund, Sweden

[3] Univ Calgary, Phoebe & Joan Snyder Inst Chron Dis, Cumming Sch Med, Dept Physiol & Pharmacol & Calvin, Calgary, AB T2N 4N1, Canada

来源：

IMMUNITY | 2017年 / 46卷 / 04期

关键词：

REGULATORY T-CELLS; ARYL-HYDROCARBON RECEPTOR; CD103(+) DENDRITIC CELLS; SEGMENTED FILAMENTOUS BACTERIA; ISOLATED LYMPHOID FOLLICLES; NONOBESE DIABETIC MICE; CHAIN FATTY-ACIDS; ROR-GAMMA-T; INTRAEPITHELIAL LYMPHOCYTES; EARLY-LIFE;

D O I：

10.1016/j.immuni.2017.04.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.

引用

页码：532 / 548

页数：17

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