Exploring the formation of Alzheimer's disease senile plaques in silico

被引：50

作者：

Edelstein-Keshet, L ^{[1
]}

Spiros, A ^{[1
]}

机构：

[1] Univ British Columbia, Dept Math, Vancouver, BC V6T 1Z2, Canada

来源：

JOURNAL OF THEORETICAL BIOLOGY | 2002年 / 216卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1006/jtbi.2002.2540

中图分类号：

Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

An experimental simulation environment suitable for exploring the neuroinflammatory hypothesis of Alzheimer's disease (AD) has been developed. Using scientific literature, we have calculated parameters and rates and constructed an interactive model system. The simulation can be manipulated to explore competing hypotheses about AD pathology, i.e. can be used as an experimental "in silico" system. In this paper, we outline the assumptions and aspects of the model, and illustrate qualitative and quantitative findings. The interactions of amyloid beta deposits, glial cell dynamics, inflammation and secreted cytokines, and the stress, recovery, and death of neuronal tissue are investigated. The model leads to qualitative insights about relative roles of the cells and chemicals in the disease pathology. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：301 / 326

页数：28

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