学术探索
学术期刊
新闻热点
数据分析
智能评审

Gli and hedgehog in cancer:: Tumours, embryos and stem cells

被引：535
作者：
Altaba, AR
Sánchez, P
Dahmane, N
机构：
[1] NYU, Sch Med, Skirball Inst, Dev Genet Program, New York, NY 10016 USA
[2] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA
[3] Univ Meditterannee, CNRS, Inst Dev Biol, UMR 6156, F-13288 Marseille, France
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 05期
关键词：
D O I：
10.1038/nrc796
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Do tumours arise from stem cells, or are they derived from more differentiated cells that, for some reason, begin to recapitulate developmental programmes? Inappropriate activation of the Sonic hedgehog-Gli signalling pathway occurs in several types of tumour, including those of the brain and the skin. Studies in these and other systems suggest that inappropriate function of the Gli transcription factors in stem or precursor cells might lead to the onset of a tumorigenic programme and that these factors are prime targets for anticancer therapies.
引用
收藏
页码：361 / 372
页数：12
相关论文
共 140 条
  • [51] Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo
    Groszer, M
    Erickson, R
    Scripture-Adams, DD
    Lesche, R
    Trumpp, A
    Zack, JA
    Kornblum, HI
    Liu, X
    Wu, H
    [J]. SCIENCE, 2001, 294 (5549) : 2186 - 2189
  • [52] Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma
    Hahn, H
    Wojnowski, L
    Specht, K
    Kappler, R
    Calzada-Wack, J
    Potter, D
    Zimmer, A
    Müller, U
    Samson, E
    Quintanilla-Martinez, L
    Zimmer, A
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (37) : 28341 - 28344
  • [53] Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    Hahn, H
    Wicking, C
    Zaphiropoulos, PG
    Gailani, MR
    Shanley, S
    Chidambaram, A
    Vorechovsky, I
    Holmberg, E
    Unden, AB
    Gillies, S
    Negus, K
    Smyth, I
    Pressman, C
    Leffell, DJ
    Gerrard, B
    Goldstein, AM
    Dean, M
    Toftgard, R
    ChenevixTrench, G
    Wainwright, B
    Bale, AE
    [J]. CELL, 1996, 85 (06) : 841 - 851
  • [54] Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
    Hahn, H
    Wojnowski, L
    Zimmer, AM
    Hall, J
    Miller, G
    Zimmer, A
    [J]. NATURE MEDICINE, 1998, 4 (05) : 619 - 622
  • [55] The hallmarks of cancer
    Hanahan, D
    Weinberg, RA
    [J]. CELL, 2000, 100 (01) : 57 - 70
  • [56] Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
    Holland, EC
    Celestino, J
    Dai, CK
    Schaefer, L
    Sawaya, RE
    Fuller, GN
    [J]. NATURE GENETICS, 2000, 25 (01) : 55 - 57
  • [57] Gliomagenesis: Genetic alterations and mouse models
    Holland, EC
    [J]. NATURE REVIEWS GENETICS, 2001, 2 (02) : 120 - 129
  • [58] Incardona JP, 1998, DEVELOPMENT, V125, P3553
  • [59] Hedgehog signaling in animal development: paradigms and principles
    Ingham, PW
    McMahon, AP
    [J]. GENES & DEVELOPMENT, 2001, 15 (23) : 3059 - 3087
  • [60] Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
    Jackson, EL
    Willis, N
    Mercer, K
    Bronson, RT
    Crowley, D
    Montoya, R
    Jacks, T
    Tuveson, DA
    [J]. GENES & DEVELOPMENT, 2001, 15 (24) : 3243 - 3248
12345678910