Shaping the actin cytoskeleton using microtubule tips

被引：67

作者：

Basu, Roshni ^{[1
]}

Chang, Fred ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2007年 / 19卷 / 01期

关键词：

D O I：

10.1016/j.ceb.2006.12.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The microtubule cytoskeleton serves as a primary spatial regulator of cell shape. As part of their function, microtubules appear to activate or inhibit the actin cytoskeleton at specific locations at the cell cortex for cell polarization, cell migration and cytokinesis. Recent studies reveal molecular insights into these processes. Regulators of the actin cytoskeleton, such as activators of formin and Rho GTPases, are transported to specific sites on the cortex by riding on the plus ends of microtubules.

引用

页码：88 / 94

页数：7

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