学术探索
学术期刊
新闻热点
数据分析
智能评审

Molecular cloning of the N-terminus of GTBP

被引：29
作者：
Nicolaides, NC
Palombo, F
Kinzler, KW
Vogelstein, B
Jiricny, J
机构：
[1] HOWARD HUGHES MED INST,BALTIMORE,MD 21231
[2] IST RIC BIOL MOLEC P ANGELETTI,I-00040 POMEZIA,ITALY
来源：
GENOMICS | 1996年 / 31卷 / 03期
关键词：
D O I：
10.1006/geno.1996.0067
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5' terminus, allowing definition of the entire coding region. Several polymorphisms within the 5' end were identified and are presented. (C) 1996 Academic Press, Inc.
引用
收藏
页码：395 / 397
页数：3
相关论文
共 13 条
  • [1] MUTATION IN THE DNA MISMATCH REPAIR GENE HOMOLOG HMLH1 IS ASSOCIATED WITH HEREDITARY NONPOLYPOSIS COLON-CANCER
    BRONNER, CE
    BAKER, SM
    MORRISON, PT
    WARREN, G
    SMITH, LG
    LESCOE, MK
    KANE, M
    EARABINO, C
    LIPFORD, J
    LINDBLOM, A
    TANNERGARD, P
    BOLLAG, RJ
    GODWIN, AR
    WARD, DC
    NORDENSKJOLD, M
    FISHEL, R
    KOLODNER, R
    LISKAY, RM
    [J]. NATURE, 1994, 368 (6468) : 258 - 261
  • [2] ISOLATION OF AN HMSH2-P160 HETERODIMER THAT RESTORES DNA MISMATCH REPAIR TO TUMOR-CELLS
    DRUMMOND, JT
    LI, GM
    LONGLEY, MJ
    MODRICH, P
    [J]. SCIENCE, 1995, 268 (5219) : 1909 - 1912
  • [3] THE HUMAN MUTATOR GENE HOMOLOG MSH2 AND ITS ASSOCIATION WITH HEREDITARY NONPOLYPOSIS COLON-CANCER
    FISHEL, R
    LESCOE, MK
    RAO, MRS
    COPELAND, NG
    JENKINS, NA
    GARBER, J
    KANE, M
    KOLODNER, R
    [J]. CELL, 1993, 75 (05) : 1027 - 1038
  • [4] A HUMAN 200-KDA PROTEIN BINDS SELECTIVELY TO DNA FRAGMENTS CONTAINING G.T MISMATCHES
    JIRICNY, J
    HUGHES, M
    CORMAN, N
    RUDKIN, BB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) : 8860 - 8864
  • [5] MUTATIONS OF A MUTS HOMOLOG IN HEREDITARY NONPOLYPOSIS COLORECTAL-CANCER
    LEACH, FS
    NICOLAIDES, NC
    PAPADOPOULOS, N
    LIU, B
    JEN, J
    PARSONS, R
    PELTOMAKI, P
    SISTONEN, P
    AALTONEN, LA
    NYSTROMLAHTI, M
    GUAN, XY
    ZHANG, J
    MELTZER, PS
    YU, JW
    KAO, FT
    CHEN, DJ
    CEROSALETTI, KM
    FOURNIER, REK
    TODD, S
    LEWIS, T
    LEACH, RJ
    NAYLOR, SL
    WEISSENBACH, J
    MECKLIN, JP
    JARVINEN, H
    PETERSEN, GM
    HAMILTON, SR
    GREEN, J
    JASS, J
    WATSON, P
    LYNCH, HT
    TRENT, JM
    DELACHAPELLE, A
    KINZLER, KW
    VOGELSTEIN, B
    [J]. CELL, 1993, 75 (06) : 1215 - 1225
  • [6] MISMATCH REPAIR, GENETIC STABILITY, AND CANCER
    MODRICH, P
    [J]. SCIENCE, 1994, 266 (5193) : 1959 - 1960
  • [7] ANALYSIS OF THE 5'-REGION OF PMS2 REVEALS HETEROGENEOUS TRANSCRIPTS AND A NOVEL OVERLAPPING GENE
    NICOLAIDES, NC
    KINZLER, KW
    VOGELSTEIN, B
    [J]. GENOMICS, 1995, 29 (02) : 329 - 334
  • [8] GENOMIC ORGANIZATION OF THE HUMAN PMS2 GENE FAMILY
    NICOLAIDES, NC
    CARTER, KC
    SHELL, BK
    PAPADOPOULOS, N
    VOGELSTEIN, B
    KINZLER, KW
    [J]. GENOMICS, 1995, 30 (02) : 195 - 206
  • [9] MUTATIONS OF 2 PMS HOMOLOGS IN HEREDITARY NONPOLYPOSIS COLON-CANCER
    NICOLAIDES, NC
    PAPADOPOULOS, N
    LIU, B
    WEI, YF
    CARTER, KC
    RUBEN, SM
    ROSEN, CA
    HASELTINE, WA
    FLEISCHMANN, RD
    FRASER, CM
    ADAMS, MD
    VENTER, JC
    DUNLOP, MG
    HAMILTON, SR
    PETERSEN, GM
    DELACHAPELLE, A
    VOGELSTEIN, B
    KINZLER, KW
    [J]. NATURE, 1994, 371 (6492) : 75 - 80
  • [10] GTBP, A 160-KILODALTON PROTEIN ESSENTIAL FOR MISMATCH-BINDING ACTIVITY IN HUMAN-CELLS
    PALOMBO, F
    GALLINARI, P
    IACCARINO, I
    LETTIERI, T
    HUGHES, M
    DARRIGO, A
    TRUONG, O
    HSUAN, JJ
    JIRICNY, J
    [J]. SCIENCE, 1995, 268 (5219) : 1912 - 1914
12