Baroreflex: A New Therapeutic Target in Human Stroke?

被引：99

作者：

Sykora, Marek ^{[1
,2
]}

Diedler, Jennifer ^{[1
]}

Turcani, Peter ^{[2
]}

Hacke, Werner ^{[1
]}

Steiner, Thorsten ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Neurol, D-69120 Heidelberg, Germany

[2] Comenius Univ, Dept Neurol, Bratislava, Slovakia

来源：

STROKE | 2009年 / 40卷 / 12期

关键词：

baroreflex sensitivity; acute stroke; heart-brain relations; outcome; therapy; HEART-RATE-VARIABILITY; CARDIAC BARORECEPTOR SENSITIVITY; DYNAMIC CEREBRAL AUTOREGULATION; BEAT BLOOD-PRESSURE; ARTERIAL BAROREFLEX; INSULAR CORTEX; BETA-BLOCKERS; PARASYMPATHETIC ACTIVITY; BRAIN-INJURY; MODULATION;

D O I：

10.1161/STROKEAHA.109.565838

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Autonomic dysfunction, including increased sympathetic drive and blunted baroreflex, has repeatedly been observed in acute stroke. Of clinical importance is that the stroke-related autonomic imbalance seems to be linked to worse outcome after stroke. Here, we discuss the role of baroreflex impairment in acute stroke and its possible pathophysiological and therapeutic relevance. Summary of Review-Possible mechanisms linking baroreflex impairment with unfavorable outcome in stroke may include increased cardiovascular morbidity and mortality, promotion of secondary brain injury due to local inflammation, hyperglycemia, or altered cerebral perfusion. Conclusions-We suggest therefore that the modifying of autonomic functions may have important therapeutic implications in acute ischemic as well as in hemorrhagic stroke. (Stroke. 2009;40:e678-e682.)

引用

页码：E678 / E682

页数：5

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