DNA methylation in animal development

被引：72

作者：

Meehan, RR ^{[1
]}

机构：

[1] Univ Edinburgh, Dept Biomed Sci, Genes & Dev Grp, Edinburgh EH8 9XD, Midlothian, Scotland

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2003年 / 14卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

DNA methylation; epigenetics; development; Dnmt methyltransferase; MBD/MeCPs; transcriptional repression;

D O I：

10.1016/S1084-9521(02)00137-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nuclear transfer experiments have demonstrated that epigenetic mechanisms operate to limit gene expression during animal development. In somatic cells, silenced genes are associated with defined chromatin states which are characterised by hypermethylation of DNA, hypoacetylation of histones and specific patterns of methylation at distinct residues of the N-terminal tails of histone H3 and H4. This review describes the role of the DNA methylation-mediated repression system (Dnmtl's, MeCPs and MBDs and associated chromatin remodelling activities) in animal development. DNA methylation is essential for normal vertebrate development but has distinct regulatory roles in non-mammalian and mammalian vertebrates. In mammals, DNA methylation has an additional role in regulating imprinting. This suggests that epigenetic regulation is plastic in its application and should be considered in a developmental context that may be species specific. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：53 / 65

页数：13

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