Recognition of platinum(II) amine complexes by nucleotides: Role of phosphate and carbonyl groups in ([N-15(3)]diethylenetriamine)-(guanosine 5'-monophosphate)platinum(II)

被引:32
作者
Guo, ZJ [1 ]
Sadler, PJ [1 ]
Zang, E [1 ]
机构
[1] UNIV LONDON, BIRKBECK COLL, DEPT CHEM, LONDON WC1H 0PP, ENGLAND
关键词
D O I
10.1039/a606275j
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Two-dimensional [H-1,N-15] NMR studies show that in the model monofunctional DNA adduct [Pt([N-15(3)]dien)(5'-GMP-N-7)](2+) [5'-GMP = guanosine 5'-monophosphate, dien = 1,5-diamino-3-azapentane (prepared by a novel synthesis from glycine)], stereospecific hydrogen-bonding interactions involving Pt-NH protons are promoted by deprotonation of both the 5'-phosphate group and NIH of coordinated 5'-GMP.
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页码:27 / 28
页数:2
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