Recognition of platinum(II) amine complexes by nucleotides: Role of phosphate and carbonyl groups in ([N-15(3)]diethylenetriamine)-(guanosine 5'-monophosphate)platinum(II)

被引：32

作者：

Guo, ZJ ^{[1
]}

Sadler, PJ ^{[1
]}

Zang, E ^{[1
]}

机构：

[1] UNIV LONDON, BIRKBECK COLL, DEPT CHEM, LONDON WC1H 0PP, ENGLAND

来源：

CHEMICAL COMMUNICATIONS | 1997年 / 01期

关键词：

D O I：

10.1039/a606275j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two-dimensional [H-1,N-15] NMR studies show that in the model monofunctional DNA adduct [Pt([N-15(3)]dien)(5'-GMP-N-7)](2+) [5'-GMP = guanosine 5'-monophosphate, dien = 1,5-diamino-3-azapentane (prepared by a novel synthesis from glycine)], stereospecific hydrogen-bonding interactions involving Pt-NH protons are promoted by deprotonation of both the 5'-phosphate group and NIH of coordinated 5'-GMP.

引用

页码：27 / 28

页数：2

共 19 条

[11] Kinetic analysis of the reactions between GG-containing oligonucleotides and platinum complexes .1. Reactions of single-stranded oligonucleotides with cis-[Pt(NH3)(2)(H2O)(2)](2+) and [Pt(NH3)(3)(H2O)](2+) [J].

Gonnet, F ;

Reeder, F ;

Kozelka, J ;

Chottard, JC .

INORGANIC CHEMISTRY, 1996, 35 (06) :1653-1658

[12] COMPLEX OF CIS-(NH3)2PTCL2 WITH GUANYLYL(3'-5')-CYTIDINE [J].

INAGAKI, K ;

KIDANI, Y .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1979, 11 (01) :39-47

[13] Hofmann's ethylene bases - Synthesis of beta beta-diaminodiethylamine and of beta beta-diaminodiethylmethylamine [J].

Mann, FG .

JOURNAL OF THE CHEMICAL SOCIETY, 1934, :461-466

[14] DISSOCIATION OF PLATINUM(II) NUCLEOBASE COMPLEXES - EVIDENCE FOR A 3-PATH MECHANISM VIA A 5-COORDINATE INTERMEDIATE [J].

MIKOLA, M ;

VIHANTO, J ;

ARPALAHTI, J .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (17) :1759-1760

[15] Reactions of the double-stranded oligonucleotide d(TTGGCCAA)(2) with cis-[Pt(NH3)(2)(H2O)(2)](2+) and [Pt(NH3)(3)(H2O)](2+) [J].

Reeder, F ;

Gonnet, F ;

Kozelka, J ;

Chottard, JC .

CHEMISTRY-A EUROPEAN JOURNAL, 1996, 2 (09) :1068-1076

[16] THE RELEVANCE OF HYDROGEN-BONDING IN THE MECHANISM OF ACTION OF PLATINUM ANTITUMOR COMPOUNDS [J].

REEDIJK, J .

INORGANICA CHIMICA ACTA, 1992, 198 :873-881

[17] UNUSUAL HYDROGEN-BONDING PATTERNS OF N-7 METALATED, N-1 DEPROTONATED GUANINE NUCLEOBASES - ACIDITY CONSTANTS OF CIS-[PT(NH3)(2)(HEGUA)(2)](2+) AND CRYSTAL-STRUCTURES OF CIS-[PT(NH3)(2)(EGUA)(2)]CENTER-DOT-4H(2)O AND CIS-[PT(NH3)(2)(EGUA)(2)]CENTER-DOT HEGUA-CENTER-DOT-7H(2)O (HEGUA=9-ETHYLGUANINE) [J].

SCHRODER, G ;

LIPPERT, B ;

SABAT, M ;

LOCK, CJL ;

FAGGIANI, R ;

SONG, B ;

SIGEL, H .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1995, (23) :3767-3775

[18] NOVEL MULTIPOINT MOLECULAR RECOGNITION OF NUCLEOBASES BY A NEW ZINC(II) COMPLEX OF ACRIDINE-PENDANT CYCLEN (CYCLEN=1,4,7,10-TETRAAZACYCLODODECANE) [J].

SHIONOYA, M ;

IKEDA, T ;

KIMURA, E ;

SHIRO, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (09) :3848-3859

[19] A NEW TERNARY ZINC(II) COMPLEX WITH [12]ANEN(4) (=1,4,7,10-TETRAAZACYCLODODECANE) AND AZT (=3'-AZIDO-3'-DEOXYTHYMIDINE) - HIGHLY SELECTIVE RECOGNITION OF THYMIDINE AND ITS RELATED NUCLEOSIDES BY A ZINC(II) MACROCYCLIC TETRAAMINE COMPLEX WITH NOVEL COMPLEMENTARY ASSOCIATIONS [J].

SHIONOYA, M ;

KIMURA, E ;

SHIRO, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (15) :6730-6737

← 1 2 →