SPINE bioinformatics and data-management aspects of high-throughput structural biology

被引：21

作者：

Albeck, S.

Alzari, P.

Andreini, C.

Banci, L.

Berry, I. M.

Bertini, I.

Cambillau, C.

Canard, B.

Carter, L.

Cohen, S. X.

Diprose, J. M.

Dym, O.

Esnouf, R. M.

Felder, C.

Ferron, F.

Guillemot, F.

Hamer, R.

Ben Jelloul, M.

Laskowski, R. A.

Laurent, T.

Longhi, S.

Lopez, R.

Luchinat, C.

Malet, H.

Mochel, T.

Morris, R. J.

Moulinier, L.

Oinn, T.

Pajon, A.

Peleg, Y.

Perrakis, A.

Poch, O.

Prilusky, J.

Rachedi, A.

Ripp, R.

Rosato, A.

Silman, I.

Stuart, D. I.

Sussman, J. L.

Thierry, J. -C.

Thompson, J. D.

Thornton, J. M.

Unger, T.

Vaughan, B.

Vranken, W.

Watson, J. D.

Whamond, G.

Henrick, K.

机构：

[1] European Bioinformat Inst, EMBL Outstn, Cambridge CB10 1SD, England

[2] Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

[3] Weizmann Inst Sci, Israel Proteom Ctr, Dept Biol Struct, IL-76100 Rehovot, Israel

[4] Inst Pasteur, Unite Biochim Struct, F-75724 Paris 15, France

[5] CERM, CIRMMP, I-50019 Sesto Fiorentino, Italy

[6] Wellcome Trust Ctr Human Genet, Div Struct Biol, Oxford OX3 7BN, England

[7] Univ Aix Marseille 1, CNRS, UMR 6098, F-13402 Marseille 20, France

[8] Univ Aix Marseille 2, F-13402 Marseille 20, France

[9] Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

来源：

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY | 2006年 / 62卷

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1107/S090744490602991X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

SPINE ( Structural Proteomics In Europe) was established in 2002 as an integrated research project to develop new methods and technologies for high- throughput structural biology. Development areas were broken down into workpackages and this article gives an overview of ongoing activity in the bioinformatics workpackage. Developments cover target selection, target registration, wet and dry laboratory data management and structure annotation as they pertain to high- throughput studies. Some individual projects and developments are discussed in detail, while those that are covered elsewhere in this issue are treated more briefly. In particular, this overview focuses on the infrastructure of the software that allows the experimentalist to move projects through different areas that are crucial to high- throughput studies, leading to the collation of large data sets which are managed and eventually archived and/ or deposited.

引用

页码：1184 / 1195

页数：12

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