The genetic contribution to non-syndromic human obesity

被引：260

作者：

Walley, Andrew J. ^{[1
]}

Asher, Julian E. ^{[1
]}

Froguel, Philippe ^{[1
,2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sect Genom Med, London W12 0NN, England

[2] Inst Pasteur, Inst Biol, CNRS8090, F-59019 Lille, France

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 07期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; LEPTIN RECEPTOR GENE; BROWN ADIPOSE-TISSUE; COPY NUMBER VARIATION; EARLY-ONSET OBESITY; SINGLE-NUCLEOTIDE POLYMORPHISMS; FTO GENE; MELANOCORTIN-4; RECEPTOR; SEQUENCE VARIANTS;

D O I：

10.1038/nrg2594

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The last few years have seen major advances in common non-syndromic obesity research, much of it the result of genetic studies. This Review outlines the competing hypotheses about the mechanisms underlying the genetic and physiological basis of obesity, and then examines the recent explosion of genetic association studies that have yielded insights into obesity, both at the candidate gene level and the genome-wide level. With obesity genetics now entering the post-genome-wide association scan era, the obvious question is how to improve the results obtained so far using single nucleotide polymorphism markers and how to move successfully into the other areas of genomic variation that may be associated with common obesity.

引用

页码：431 / 442

页数：12

共 152 条

[1] A haplotype map of the human genome [J].

Altshuler, D ;

Brooks, LD ;

Chakravarti, A ;

Collins, FS ;

Daly, MJ ;

Donnelly, P ;

Gibbs, RA ;

Belmont, JW ;

Boudreau, A ;

Leal, SM ;

Hardenbol, P ;

Pasternak, S ;

Wheeler, DA ;

Willis, TD ;

Yu, FL ;

Yang, HM ;

Zeng, CQ ;

Gao, Y ;

Hu, HR ;

Hu, WT ;

Li, CH ;

Lin, W ;

Liu, SQ ;

Pan, H ;

Tang, XL ;

Wang, J ;

Wang, W ;

Yu, J ;

Zhang, B ;

Zhang, QR ;

Zhao, HB ;

Zhao, H ;

Zhou, J ;

Gabriel, SB ;

Barry, R ;

Blumenstiel, B ;

Camargo, A ;

Defelice, M ;

Faggart, M ;

Goyette, M ;

Gupta, S ;

Moore, J ;

Nguyen, H ;

Onofrio, RC ;

Parkin, M ;

Roy, J ;

Stahl, E ;

Winchester, E ;

Ziaugra, L ;

Shen, Y .

NATURE, 2005, 437 (7063) :1299-1320

[2] Relevance of Niemann-Pick type C1 protein expression in controlling plasma cholesterol and biliary lipid secretion in mice [J].

Amigo, L ;

Mendoza, H ;

Castro, J ;

Quiñones, V ;

Miquel, JF ;

Zanlungo, S .

HEPATOLOGY, 2002, 36 (04) :819-828

[3] Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation [J].

Andreasen, Camilla H. ;

Stender-Petersen, Kirstine L. ;

Mogensen, Mette S. ;

Torekov, Signe S. ;

Wegner, Lise ;

Andersen, Gitte ;

Nielsen, Arne L. ;

Albrechtsen, Anders ;

Borch-Johnsen, Knut ;

Rasmussen, Signe S. ;

Clausen, Jesper O. ;

Sandbaek, Annelli ;

Lauritzen, Torsten ;

Hansen, Lars ;

Jorgensen, Torben ;

Pedersen, Oluf ;

Hansen, Torben .

DIABETES, 2008, 57 (01) :95-101

[4] Non-Replication of Genome-Wide Based Associations between Common Variants in INSIG2 and PFKP and Obesity in Studies of 18,014 Danes [J].

Andreasen, Camilla H. ;

Mogensen, Mette S. ;

Borch-Johnsen, Knut ;

Sandbaek, Annelli ;

Lauritzen, Torsten ;

Sorensen, Thorkild I. A. ;

Hansen, Lars ;

Almind, Katrine ;

Jorgensen, Torben ;

Pedersen, Oluf ;

Hansen, Torben .

PLOS ONE, 2008, 3 (08)

[5] Genetic linkage and association of the growth hormone secretagogue receptor (Ghrelin receptor) gene in human obesity [J].

Baessler, A ;

Hasinoff, MJ ;

Fischer, M ;

Reinhard, W ;

Sonnenberg, GE ;

Olivier, M ;

Erdmann, J ;

Schunkert, H ;

Doering, A ;

Jacob, HJ ;

Comuzzie, AG ;

Kissebah, AH ;

Kwitek, AE .

DIABETES, 2005, 54 (01) :259-267

[6] Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data [J].

Baross, Agnes ;

Delaney, Allen D. ;

Li, H. Irene ;

Nayar, Tarun ;

Flibotte, Stephane ;

Qian, Hong ;

Chan, Susanna Y. ;

Asano, Jennifer ;

Ally, Adrian ;

Cao, Manqiu ;

Birch, Patricia ;

Brown-John, Mabel ;

Fernandes, Nicole ;

Go, Anne ;

Kennedy, Giulia ;

Langlois, Sylvie ;

Eydoux, Patrice ;

Friedman, J. M. ;

Marra, Marco A. .

BMC BIOINFORMATICS, 2007, 8 (1)

[7] The genetics of human obesity [J].

Bell, CG ;

Walley, AJ ;

Froguel, P .

NATURE REVIEWS GENETICS, 2005, 6 (03) :221-234

[8] Common nonsynonymous variants in PCSK1 confer risk of obesity [J].

Benzinou, Michael ;

Creemers, John W. M. ;

Choquet, Helene ;

Lobbens, Stephane ;

Dina, Christian ;

Durand, Emmanuelle ;

Guerardel, Audrey ;

Boutin, Philippe ;

Jouret, Beatrice ;

Heude, Barbara ;

Balkau, Beverley ;

Tichet, Jean ;

Marre, Michel ;

Potoczna, Natascha ;

Horber, Fritz ;

Le Stunff, Catherine ;

Czernichow, Sebastien ;

Sandbaek, Annelli ;

Lauritzen, Torsten ;

Borch-Johnsen, Knut ;

Andersen, Gitte ;

Kiess, Wieland ;

Koerner, Antje ;

Kovacs, Peter ;

Jacobson, Peter ;

Carlsson, Lena M. S. ;

Walley, Andrew J. ;

Jorgensen, Torben ;

Hansen, Torben ;

Pedersen, Oluf ;

Meyre, David ;

Froguel, Philippe .

NATURE GENETICS, 2008, 40 (08) :943-945

[9] Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations [J].

Benzinou, Michael ;

Chevre, Jean-Claude ;

Ward, Kirsten J. ;

Lecoeur, Cecile ;

Dina, Christian ;

Lobbens, Stephane ;

Durand, Emmanuelle ;

Delplanque, Jerome ;

Horber, Fritz F. ;

Heude, Barbara ;

Balkau, Beverley ;

Borch-Johnsen, Knut ;

Jorgensen, Torben ;

Hansen, Torben ;

Pedersen, Oluf ;

Meyre, David ;

Froguel, Philippe .

HUMAN MOLECULAR GENETICS, 2008, 17 (13) :1916-1921

[10] High-throughput DNA methylation profiling using universal bead arrays [J].

Bibikova, M ;

Lin, ZW ;

Zhou, LX ;

Chudin, E ;

Garcia, EW ;

Wu, B ;

Doucet, D ;

Thomas, NJ ;

Wang, YH ;

Vollmer, E ;

Goldmann, T ;

Seifart, C ;

Jiang, W ;

Barker, DL ;

Chee, MS ;

Floros, J ;

Fan, JB .

GENOME RESEARCH, 2006, 16 (03) :383-393

← 1 2 3 4 5 6 7 8 9 10 →