The genetic contribution to non-syndromic human obesity

被引：260

作者：

Walley, Andrew J. ^{[1
]}

Asher, Julian E. ^{[1
]}

Froguel, Philippe ^{[1
,2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sect Genom Med, London W12 0NN, England

[2] Inst Pasteur, Inst Biol, CNRS8090, F-59019 Lille, France

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 07期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; LEPTIN RECEPTOR GENE; BROWN ADIPOSE-TISSUE; COPY NUMBER VARIATION; EARLY-ONSET OBESITY; SINGLE-NUCLEOTIDE POLYMORPHISMS; FTO GENE; MELANOCORTIN-4; RECEPTOR; SEQUENCE VARIANTS;

D O I：

10.1038/nrg2594

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The last few years have seen major advances in common non-syndromic obesity research, much of it the result of genetic studies. This Review outlines the competing hypotheses about the mechanisms underlying the genetic and physiological basis of obesity, and then examines the recent explosion of genetic association studies that have yielded insights into obesity, both at the candidate gene level and the genome-wide level. With obesity genetics now entering the post-genome-wide association scan era, the obvious question is how to improve the results obtained so far using single nucleotide polymorphism markers and how to move successfully into the other areas of genomic variation that may be associated with common obesity.

引用

页码：431 / 442

页数：12

共 152 条

[11]

BLAKEMORE AI, OBESITY SIL IN PRESS

[12] Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals [J].

Boden, Guenther ;

Duan, Xanbao ;

Homko, Carol ;

Molina, Ezequiel J. ;

Song, WeiWei ;

Perez, Oscar ;

Cheung, Peter ;

Merali, Salim .

DIABETES, 2008, 57 (09) :2438-2444

[13] ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity [J].

Bouatia-Naji, N ;

Meyre, D ;

Lobbens, S ;

Séron, K ;

Fumeron, F ;

Balkau, B ;

Heude, B ;

Jouret, B ;

Scherer, PE ;

Dina, C ;

Weill, J ;

Froguel, P .

DIABETES, 2006, 55 (02) :545-550

[14] GAD2 on chromosome 10p12 is a candidate gene for human obesity [J].

Boutin, P ;

Dina, C ;

Vasseur, F ;

Dubois, S ;

Corset, L ;

Séron, K ;

Bekris, L ;

Cabellon, J ;

Neve, B ;

Vasseur-Delannoy, V ;

Chikri, M ;

Charles, MA ;

Clement, K ;

Lernmark, A ;

Froguel, P .

PLOS BIOLOGY, 2003, 1 (03) :361-371

[15] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[16] TCF7L2 Genetic Defect and Type 2 Diabetes [J].

Cauchi, Stephane ;

Froguel, Philippe .

CURRENT DIABETES REPORTS, 2008, 8 (02) :149-155

[17] Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE Family Study [J].

Chagnon, YC ;

Wilmore, JH ;

Borecki, IB ;

Gagnon, J ;

Pérusse, L ;

Chagnon, M ;

Collier, GR ;

Leon, AS ;

Skinner, JS ;

Rao, DC ;

Bouchard, C .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (01) :29-34

[18] A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism [J].

Challis, BG ;

Pritchard, LE ;

Creemers, JWM ;

Delplanque, J ;

Keogh, JM ;

Luan, J ;

Wareham, NJ ;

Yeo, GSH ;

Bhattacharyya, S ;

Froguel, P ;

White, A ;

Farooqi, IS ;

O'Rahilly, S .

HUMAN MOLECULAR GENETICS, 2002, 11 (17) :1997-2004

[19] Common genetic variation near MC4R is associated with waist circumference and insulin resistance [J].

Chambers, John C. ;

Elliott, Paul ;

Zabaneh, Delilah ;

Zhang, Weihua ;

Li, Yun ;

Froguel, Philippe ;

Balding, David ;

Scott, James ;

Kooner, Jaspal S. .

NATURE GENETICS, 2008, 40 (06) :716-718

[20] A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction [J].

Clément, K ;

Vaisse, C ;

Lahlou, N ;

Cabrol, S ;

Pelloux, V ;

Cassuto, D ;

Gourmelen, M ;

Dina, C ;

Chambaz, J ;

Lacorte, JM ;

Basdevant, A ;

Bougneres, P ;

Lebouc, Y ;

Froguel, P ;

Guy-Grand, B .

NATURE, 1998, 392 (6674) :398-401

← 1 2 3 4 5 6 7 8 9 10 →