Clinical Relevance of β2-Glycoprotein-I Plasma Levels in Antiphospholipid Syndrome (APS)

被引：14

作者：

Banzato, Alessandra ^{[1
]}

Pengo, Vittorio ^{[1
]}

机构：

[1] Univ Padua, Dept Cardiac Thorac & Vasc Sci, I-35128 Padua, Italy

来源：

CURRENT RHEUMATOLOGY REPORTS | 2014年 / 16卷 / 06期

关键词：

Beta-2-glycoprotein I; Antiphospholipid syndrome; Plasma levels; APS; Antiphospholipid antibodies; Thrombosis; ANTICARDIOLIPIN ANTIBODIES; CRYSTAL-STRUCTURE; LIVER-CIRRHOSIS; PROTEIN-C; BETA-2-GLYCOPROTEIN-I; PREVALENCE; METABOLISM; THROMBIN; BINDING; RAT;

D O I：

10.1007/s11926-014-0424-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antiphospholipid synd rome (APS) is characterized by the presence of antiphospholipid (aPL) antibodies associated with thrombosis or pregnancy morbidity. The antibodies mainly involved in this disorder are directed against beta(2)-glycoprotein I (beta(2)-GPI). beta(2)-GPI plasma level is usually not reported in studies on APS, because it is not regarded as relevant to the diagnosis and prognosis of APS. Nevertheless its measurement may be important for understanding the pathophysiology of the syndrome. This review summarizes available data from the literature on plasma concentrations of beta(2)-GPI in patients with different antibody profiles.

引用

页数：5

共 27 条

[11] Circulating levels of β2-glycoprotein I in thrombotic disorders and in inflammation [J].

Lin, F ;

Murphy, R ;

White, B ;

Kelly, J ;

Feighery, C ;

Doyle, R ;

Pittock, S ;

Moroney, J ;

Smith, O ;

Livingstone, W ;

Keenan, C ;

Jackson, J .

LUPUS, 2006, 15 (02) :87-93

[12] COMPLETE AMINO-ACID-SEQUENCE OF HUMAN-PLASMA BETA-2-GLYCOPROTEIN-I [J].

LOZIER, J ;

TAKAHASHI, N ;

PUTNAM, FW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (12) :3640-3644

[13] ELEVATED LEVELS OF BETA(2) GLYCOPROTEIN-I (BETA(2)GPI) IN ANTIPHOSPHOLIPID ANTIBODY SYNDROME ARE DUE TO INCREASED AMOUNTS OF BETA(2)GPI IN ASSOCIATION WITH OTHER PLASMA CONSTITUENTS [J].

MCNALLY, T ;

MACKIE, IJ ;

MACHIN, SJ ;

ISENBERG, DA .

BLOOD COAGULATION & FIBRINOLYSIS, 1995, 6 (05) :411-416

[14]

McNally T, 1995, BRIT J RHEUMATOL, V34, P1031

[15] Genetic variation in the apolipoprotein H (β2-glycoprotein I) gene affects plasma apolipoprotein H concentrations [J].

Mehdi, H ;

Aston, CE ;

Sanghera, DK ;

Hamman, RF ;

Kamboh, MI .

HUMAN GENETICS, 1999, 105 (1-2) :63-71

[16] A functional polymorphism at the transcriptional initiation site in β2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of β2-glycoprotein I [J].

Mehdi, H ;

Manzi, S ;

Desai, P ;

Chen, Q ;

Nestlerode, C ;

Bontempo, F ;

Strom, SC ;

Zarnegar, R ;

Kamboh, MI .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2003, 270 (02) :230-238

[17]

Mori T, 1996, THROMB HAEMOSTASIS, V75, P49

[18] β2-Glycoprotein I binds to thrombin and selectively inhibits the enzyme procoagulant functions [J].

Pozzi, N. ;

Acquasaliente, L. ;

Frasson, R. ;

Cristiani, A. ;

Moro, S. ;

Banzato, A. ;

Pengo, V. ;

Scaglione, G. L. ;

Arcovito, A. ;

De Cristofaro, R. ;

De Filippis, V. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2013, 11 (06) :1093-1102

[19]

SCHULTZE H E, 1961, Bibl Haematol, V12, P197

[20]

SCHULTZE HE, 1961, B SCHWEIZ AKAD MED, V17, P77

← 1 2 3 →