En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition

被引：271

作者：

Aceto, Nicola ^{[1
,2
]}

Toner, Mehmet ^{[3
,4
,5
]}

Maheswaran, Shyamala ^{[1
,3
]}

Haber, Daniel A. ^{[1
,2
,6
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Canc Ctr, Boston, MA 02129 USA

[2] Harvard Med Sch, Dept Med, Boston, MA 02129 USA

[3] Harvard Med Sch, Dept Surg, Boston, MA 02129 USA

[4] Harvard Med Sch, Ctr Engn Med, Boston, MA 02129 USA

[5] Shriners Hosp Children, Boston, MA 02129 USA

[6] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

来源：

TRENDS IN CANCER | 2015年 / 1卷 / 01期

关键词：

BREAST-CANCER; MOLECULAR CHARACTERIZATION; PERIPHERAL-BLOOD; GAMMA-CATENIN; LABEL-FREE; SURVIVAL; EXPRESSION; MIGRATION; GROWTH; DEVICE;

D O I：

10.1016/j.trecan.2015.07.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Blood-borne metastasis accounts for the vast majority of cancer-related deaths and it is fueled by the generation of circulating tumor cells (CTCs) from a primary tumor deposit. Recent technological advances have made it possible to characterize human CTCs as they travel within the bloodstream. CTCs are found both as single cells and as clusters of cells held together by intercellular junctions. Although less prevalent, CTC clusters appear to have greater metastatic potential than single CTCs in the circulation. Both may exhibit shifts in expression of epithelial and mesenchymal markers, which may show dynamic changes during cancer progression. In this review we discuss recent insights into the biological properties of individual and clustered cancer cells in the circulation.

引用

页码：44 / 52

页数：9

共 82 条

[1]

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis [J].

Aceto, Nicola ;

Bardia, Aditya ;

Miyamoto, David T. ;

Donaldson, Maria C. ;

Wittner, Ben S. ;

Spencer, Joel A. ;

Yu, Min ;

Pely, Adam ;

Engstrom, Amanda ;

Zhu, Huili ;

Brannigan, Brian W. ;

Kapur, Ravi ;

Stott, Shannon L. ;

Shioda, Toshi ;

Ramaswamy, Sridhar ;

Ting, David T. ;

Lin, Charles P. ;

Toner, Mehmet ;

Haber, Daniel A. ;

Maheswaran, Shyamala .

CELL, 2014, 158 (05) :1110-1122

[2]

Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis [J].

Al-Mehdi, AB ;

Tozawa, K ;

Fisher, AB ;

Shientag, L ;

Lee, A ;

Muschel, RJ .

NATURE MEDICINE, 2000, 6 (01) :100-102

[3]

ALBINI A, 1987, CANCER RES, V47, P3239

[4]

Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model [J].

Alexander, Stephanie ;

Koehl, Gudrun E. ;

Hirschberg, Markus ;

Geissler, Edward K. ;

Friedl, Peter .

HISTOCHEMISTRY AND CELL BIOLOGY, 2008, 130 (06) :1147-1154

[5]

OPINION Challenges in circulating tumour cell research [J].

Alix-Panabieres, Catherine ;

Pantel, Klaus .

NATURE REVIEWS CANCER, 2014, 14 (09) :623-631

[6]

Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence [J].

Ansieau, Stephane ;

Bastid, Jeremy ;

Doreau, Agnes ;

Morel, Anne-Pierre ;

Bouchet, Benjamin P. ;

Thomas, Clemence ;

Fauvet, Frederique ;

Puisieux, Isabelle ;

Doglioni, Claudio ;

Piccinin, Sara ;

Maestro, Roberta ;

Voeltzel, Thibault ;

Selmi, Abdelkader ;

Valsesia-Wittmann, Sandrine ;

de Fromentel, Claude Caron ;

Puisieux, Alain .

CANCER CELL, 2008, 14 (01) :79-89

[7]

Ashworth T., 1869, AUST MED J, V14, P146

[8]

Circulating tumor cell enumeration by the CellSearch system: The clinician's guide to breast cancer treatment? [J].

Beije, Nick ;

Jager, Agnes ;

Sleijfer, Stefan .

CANCER TREATMENT REVIEWS, 2015, 41 (02) :144-150

[9]

Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data [J].

Bidard, Francois-Clement ;

Peeters, Dieter J. ;

Fehm, Tanja ;

Nole, Franco ;

Gisbert-Criado, Rafael ;

Mavroudis, Dimitrios ;

Grisanti, Salvatore ;

Generali, Daniele ;

Garcia-Saenz, Jose A. ;

Stebbing, Justin ;

Caldas, Carlos ;

Gazzaniga, Paola ;

Manso, Luis ;

Zamarchi, Rita ;

Fernandez de Lascoiti, Angela ;

De Mattos-Arruda, Leticia ;

Ignatiadis, Michail ;

Lebofsky, Ronald ;

van Laere, Steven J. ;

Meier-Stiegen, Franziska ;

Sandri, Maria-Teresa ;

Vidal-Martinez, Jose ;

Politaki, Eleni ;

Consoli, Francesca ;

Bottini, Alberto ;

Diaz-Rubio, Eduardo ;

Krell, Jonathan ;

Dawson, Sarah-Jane ;

Raimondi, Cristina ;

Rutten, Annemie ;

Janni, Wolfgang ;

Munzone, Elisabetta ;

Caranana, Vicente ;

Agelaki, Sofi A. ;

Almici, Camillo ;

Dirix, Luc ;

Solomayer, Erich-Franz ;

Zorzino, Laura ;

Johannes, Helene ;

Reis-Filho, Jorge S. ;

Pantel, Klaus ;

Pierga, Jean-Yves ;

Michiels, Stefan .

LANCET ONCOLOGY, 2014, 15 (04) :406-414

[10]

To differentiate or not - routes towards metastasis [J].

Brabletz, Thomas .

NATURE REVIEWS CANCER, 2012, 12 (06) :425-436

← 1 2 3 4 5 6 7 8 9 →