High-throughput cell analysis using multiplexed array technologies

被引：42

作者：

Beske, OE ^{[1
]}

Goldbard, S ^{[1
]}

机构：

[1] Virtual Arrays, Sunnyvale, CA 94089 USA

来源：

DRUG DISCOVERY TODAY | 2002年 / 7卷 / 18期

关键词：

D O I：

10.1016/S1359-6446(02)02388-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The desire for more biologically relevant data from primary screening has resulted in a dramatic increase of cell-based assays in HTS labs. Consequently, new cell-array technologies are being developed to increase the quality and quantity of data emerging from such screens. These technologies take the form of both positional and non-positional formats, each with their own advantages. Notably, screens using these technologies generate databases of high-quality data that can be analyzed in ways currently not possible. The power of cell-based assays combined with new array and analytical technologies will enable the condensation of serial drug discovery processes, thereby decreasing the time and cost of taking a hit compound into clinical trials. Here, we compare array strategies being developed towards the goal of integrating multiplexed cell-based assays into HTS.

引用

页码：S131 / S135

页数：5

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