A convenient synthesis of pseudoceratidine and three analogs for biological evaluation.

被引：12

作者：

Behrens, C ^{[1
]}

Christoffersen, MW ^{[1
]}

Gram, L ^{[1
]}

Nielsen, PH ^{[1
]}

机构：

[1] DANISH INST FISHERIES RES,DEPT SEAFOOD RES,DK-2800 LYNGBY,DENMARK

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(96)00622-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The recently isolated marine natural product pseudoceratidine (1) has been synthesized from 2-trichloroacetylpyrrole. Bromination in the 4- and 5-position followed by nucleophilic displacement of the trichloromethyl group with spermidine gave 1 in 79% yield. The procedure is general and can easily be adopted to the preparation of other derivatives. This was demonstrated by the synthesis of a 5,5'-didebromo derivative (2) and two analogs (3-4). The compounds 1-4 have been tested for antibacterial activity and the results compared to a previous study. Also activity against the marine brine shrimp Artemia salina is reported. (C) 1997, Elsevier Science Ltd.

引用

页码：321 / 326

页数：6

共 7 条

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