Wall Teichoic Acid Protects Staphylococcus aureus against Antimicrobial Fatty Acids from Human Skin

被引：78

作者：

Kohler, Thomas ^{[1
]}

Weidenmaier, Christopher ^{[2
]}

Peschel, Andreas ^{[1
]}

机构：

[1] Univ Tubingen, Med Microbiol & Hyg Inst, Cellular & Mol Microbiol Div, Tubingen, Germany

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

JOURNAL OF BACTERIOLOGY | 2009年 / 191卷 / 13期

关键词：

GRAM-POSITIVE BACTERIA; STRATUM-CORNEUM LIPIDS; NASAL COLONIZATION; INFECTIONS; RESISTANCE; PROTEINS; DEFENSE; EVASION; ROLES;

D O I：

10.1128/JB.00221-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Skin-colonizing gram-positive bacteria produce wall teichoic acids (WTAs) or related glycopolymers for unclear reasons. Using a WTA-deficient Staphylococcus aureus mutant, we demonstrated that WTA confers resistance to antimicrobial fatty acids from human sebaceous glands by preventing fatty acid binding. Thus, WTA is probably important for bacterial skin colonization.

引用

页码：4482 / 4484

页数：3

共 24 条

[1] Genetic regulation of fatty acid modifying enzyme from Staphylococcus aureus [J].

Chamberlain, NR ;

Imanoel, B .

JOURNAL OF MEDICAL MICROBIOLOGY, 1996, 44 (02) :125-129

[2] The Staphylococcus aureus surface protein IsdA mediates resistance to innate Defenses of human skin [J].

Clarke, Simon R. ;

Mohamed, Ramlan ;

Bian, Li ;

Routh, Alexander F. ;

Kokai-Kun, John F. ;

Mond, James J. ;

Tarkowski, Andrei ;

Foster, Simon J. .

CELL HOST & MICROBE, 2007, 1 (03) :199-212

[3] Skin microbiota: a source of disease or defence? [J].

Cogen, A. L. ;

Nizet, V. ;

Gallo, R. L. .

BRITISH JOURNAL OF DERMATOLOGY, 2008, 158 (03) :442-455

[4] Immune evasion by Staphylococci [J].

Foster, TJ .

NATURE REVIEWS MICROBIOLOGY, 2005, 3 (12) :948-958

[5] 2 RESTRICTION AND MODIFICATION SYSTEMS IN STAPHYLOCOCCUS-AUREUS NCTC8325 [J].

IORDANESCU, S ;

SURDEANU, M .

JOURNAL OF GENERAL MICROBIOLOGY, 1976, 96 (OCT) :277-281

[6] Fatty acids and Monoacylglycerols inhibit growth of Staphylococcus aureus [J].

Kelsey, J. A. ;

Bayles, K. W. ;

Shafii, B. ;

McGuire, M. A. .

LIPIDS, 2006, 41 (10) :951-961

[7] Wall teichoic acid deficiency in Staphylococcus aureus confers selective resistance to mammalian group IIA phospholipase A2 and human p-defensin 3 [J].

Koprivnjak, Tomaz ;

Weidenmaier, Christopher ;

Peschel, Andreas ;

Weiss, Jerrold P. .

INFECTION AND IMMUNITY, 2008, 76 (05) :2169-2176

[8] Staphylococcus aureus evasion of innate antimicrobial defense [J].

Kraus, Dirk ;

Peschel, Andreas .

FUTURE MICROBIOLOGY, 2008, 3 (04) :437-451

[9]

LAMPE MA, 1983, J LIPID RES, V24, P120

[10] Medical progress -: Staphylococcus aureus infections [J].

Lowy, FD .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (08) :520-532

← 1 2 3 →