Wall Teichoic Acid Protects Staphylococcus aureus against Antimicrobial Fatty Acids from Human Skin

被引：78

作者：

Kohler, Thomas ^{[1
]}

Weidenmaier, Christopher ^{[2
]}

Peschel, Andreas ^{[1
]}

机构：

[1] Univ Tubingen, Med Microbiol & Hyg Inst, Cellular & Mol Microbiol Div, Tubingen, Germany

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

JOURNAL OF BACTERIOLOGY | 2009年 / 191卷 / 13期

关键词：

GRAM-POSITIVE BACTERIA; STRATUM-CORNEUM LIPIDS; NASAL COLONIZATION; INFECTIONS; RESISTANCE; PROTEINS; DEFENSE; EVASION; ROLES;

D O I：

10.1128/JB.00221-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Skin-colonizing gram-positive bacteria produce wall teichoic acids (WTAs) or related glycopolymers for unclear reasons. Using a WTA-deficient Staphylococcus aureus mutant, we demonstrated that WTA confers resistance to antimicrobial fatty acids from human sebaceous glands by preventing fatty acid binding. Thus, WTA is probably important for bacterial skin colonization.

引用

页码：4482 / 4484

页数：3

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