Cell biology - Reeling CASK into the nucleus

被引:13
作者
Bredt, DS [1 ]
机构
[1] Univ Calif San Francisco, Sch Med, Dept Physiol, San Francisco, CA 94143 USA
关键词
D O I
10.1038/35005208
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cells send messages to their neighbours through ‘junctional complexes’, which link molecules on the cell surface to the cytoskeleton beneath. One of the proteins that forms these complexes, CASK, is now shown to travel from the cell surface to the nucleus, where it regulates gene expression by binding to DNA.
引用
收藏
页码:241 / 242
页数:2
相关论文
共 10 条
  • [1] An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons
    Bulfone, A
    Wang, F
    Hevner, R
    Anderson, S
    Cutforth, T
    Chen, S
    Meneses, J
    Pedersen, R
    Axel, R
    Rubenstein, JLR
    [J]. NEURON, 1998, 21 (06) : 1273 - 1282
  • [2] Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells
    Cohen, AR
    Wood, DF
    Marfatia, SM
    Walther, Z
    Chishti, AH
    Anderson, JM
    [J]. JOURNAL OF CELL BIOLOGY, 1998, 142 (01) : 129 - 138
  • [3] PDZ proteins organize synaptic signaling pathways
    Craven, SE
    Bredt, DS
    [J]. CELL, 1998, 93 (04) : 495 - 498
  • [4] A PROTEIN RELATED TO EXTRACELLULAR-MATRIX PROTEINS DELETED IN THE MOUSE MUTANT REELER
    DARCANGELO, G
    MIAO, GG
    CHEN, SC
    SOARES, HD
    MORGAN, JI
    CURRAN, T
    [J]. NATURE, 1995, 374 (6524) : 719 - 723
  • [5] Review: Neurobiology - The presenilins in Alzheimer's disease - Proteolysis holds the key
    Haass, C
    De Strooper, B
    [J]. SCIENCE, 1999, 286 (5441) : 916 - 919
  • [6] Hata Y, 1996, J NEUROSCI, V16, P2488
  • [7] Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2
    Hsueh, YP
    Wang, TF
    Yang, FC
    Sheng, M
    [J]. NATURE, 2000, 404 (6775) : 298 - 302
  • [8] THE T-PROTEIN ENCODED BY BRACHYURY IS A TISSUE-SPECIFIC TRANSCRIPTION FACTOR
    KISPERT, A
    KOSCHORZ, B
    HERRMANN, BG
    [J]. EMBO JOURNAL, 1995, 14 (19) : 4763 - 4772
  • [9] A versatile transcriptional effector of wingless signaling
    Nusse, R
    [J]. CELL, 1997, 89 (03) : 321 - 323
  • [10] BDNF regulates Reelin expression and Cajal-Retzius cell development in the cerebral cortex
    Ringstedt, T
    Linnarsson, S
    Wagner, J
    Lendahl, U
    Kokaia, Z
    Arenas, E
    Ernfors, P
    Ibáñez, CF
    [J]. NEURON, 1998, 21 (02) : 305 - 315