Pathogenic MOG-reactive CD8+T cells require MOG-reactive CD4+T cells for sustained CNS inflammation during chronic EAE

被引：28

作者：

Bettini, Maria ^{[2
]}

Rosenthal, Kristen ^{[1
]}

Evavold, Brian D. ^{[1
]}

机构：

[1] Emory Univ, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[2] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 213卷 / 1-2期

关键词：

T cell; Central nervous system; Experimental autoimmune encephalomyelitis; Myelin oligodendrocyte protein; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MYELIN BASIC-PROTEIN; CD8(+) T-CELLS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; OLIGODENDROCYTE GLYCOPROTEIN MOG; CLASS-I MOLECULES; MULTIPLE-SCLEROSIS; DEMYELINATING DISEASE; CLONAL EXPANSIONS; DEFICIENT MICE;

D O I：

10.1016/j.jneuroim.2009.05.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

XIncreasing evidence supports a role for CD8+ T cells in multiple sclerosis. In an attempt to isolate the contribution of CD8+ T cells in a murine model of MS, we immunized mice with a dominant CD8 epitope MOG37-46, a truncated version of MOG35-55. The data presented here show mild disease induced with MOG37-46, characterized by lower clinical scores, a decrease in CNS infiltration and a decrease in microglial activation. CD8+ T cells reactive to MOG37-46 are pro-inflammatory and traffic to the CNS; however, the presence of CD4+ T cells elicits more severe disease and sustained inflammation of the CNS. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：60 / 68

页数：9

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