Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

被引：159

作者：

Mantovani, A

Allavena, P

Sozzani, S

Vecchi, A

Locati, M

Sica, A

机构：

[1] Mario Negri Inst Pharmacol Res, Dept Immunol & Cell Biol, I-20157 Milan, Italy

[2] Univ Milan, Fac Med, Ctr Eccellenza Innovaz Diagnost & Terapeut, IDET,Inst Gen Pathol, I-20133 Milan, Italy

[3] Univ Brescia, Sect Gen Pathol & Immunol, I-25123 Brescia, Italy

来源：

SEMINARS IN CANCER BIOLOGY | 2004年 / 14卷 / 03期

关键词：

chemokines; recruitment; infiltrating leukocytes;

D O I：

10.1016/j.semcancer.2003.10.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：155 / 160

页数：6

共 71 条

[61] The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages [J].