Causes of arterial hypertension and splachnic ischemia during acute elevations in intra-abdominal pressure with CO2 pneumoperitoneum:: a complex central nervous system mediated response

The application of laparoscopic technique has gained popularity in the past decade. Numerous studies have qualified and quantified the systemic impact of acutely elevated intra-abdominal pressure during pneumoperitoneum at time of laparoscopy. The major hemodynamic effects are increased central venous pressure, increased systemic vascular resistance and systemic hypertension. Reductions in splanchnic and renal blood flow have also been documented, but the clinical significance of these observations is not clear and required further investigation. In our previous work we demonstrated intracranial hypertension secondary to acute elevation in intra-abdominal pressure and described the pathophysiology. Elevated intra-abdominal pressure during induced pneumoperitomeum can serve as a basic model for other disease processes which are characterized by acute or chronic abdominal hypertension. Here we review the current literature and describe our own experience to suggest a unifying model, with emphasis on the key role of the central nervous system in mediating the systemic response to increased intra-abdominal pressure.