Extracellular vesicles: New players in cardiovascular diseases

被引：56

作者：

Gaceb, Abderahim ^{[1
]}

Martinez, Maria Carmen ^{[1
]}

Andriantsitohaina, Ramaroson ^{[1
,2
]}

机构：

[1] Univ Angers, INSERM, UMR1063, Angers, France

[2] CHU Angers, Angers, France

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2014年 / 50卷

关键词：

Extracellular vesicles; Cardiovascular diseases; Vascular cells; Myocardium; PLATELET-DERIVED MICROPARTICLES; CIRCULATING MICROPARTICLES; ENDOTHELIAL DYSFUNCTION; APOPTOTIC BODIES; MICROVESICLES; EXOSOMES; CELLS; INJURY;

D O I：

10.1016/j.biocel.2014.01.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Extracellular vesicles, particles released by all cell types, represent a new way to convey information between cells such as proteins, second messengers, and genetic information to modify the phenotype and function of the target cells. Recent data suggest that extracellular vesicles play a crucial role in both physiology and pathology, including coagulation, angiogenesis, cell survival, modulation of the immune response, and inflammation. Thus extracellular vesicles participate in the processes of cardiovascular diseases from atherosclerosis, myocardial infarction to heart failure. Consequently, extracellular vesicles can potentially be exploited for therapy, prognosis, and biomarkers for health and disease. This review focuses on the role of extracellular vesicles in the development of cardiovascular diseases, as well as the deleterious and beneficial effects that they may provide in vascular cells and myocardium. (C) 2014 Elsevier Ltd. All rights reserved.

引用

收藏

页码：24 / 28

页数：5

相关论文

共 33 条

[1]

Enclothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome [J].

Agouni, Abdelali ;

Lagrue-Lak-Hal, Anne Helene ;

Ducluzeau, Pierre Henri ;

Mostefai, Hadj Ahmed ;

Draunet-Busson, Catherine ;

Leftheriotis, Georges ;

Heymes, Christophe ;

Martinez, Maria Carmen ;

Andriantsitohaina, Ramaroson .

AMERICAN JOURNAL OF PATHOLOGY, 2008, 173 (04) :1210-1219

[2]

Microparticles from Patients with Metabolic Syndrome Induce Vascular Hypo-Reactivity via Fas/Fas-Ligand Pathway in Mice [J].

Agouni, Abdelali ;

Ducluzeau, Pierre-Henri ;

Benameur, Tarek ;

Faure, Sebastien ;

Sladkova, Martina ;

Duluc, Lucie ;

Leftheriotis, Georges ;

Pechanova, Olga ;

Delibegovic, Mirela ;

Martinez, Maria Carmen ;

Andriantsitohaina, Ramaroson .

PLOS ONE, 2011, 6 (11)

[3]

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies [J].

Akers, Johnny C. ;

Gonda, David ;

Kim, Ryan ;

Carter, Bob S. ;

Chen, Clark C. .

JOURNAL OF NEURO-ONCOLOGY, 2013, 113 (01) :1-11

[4]

Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure [J].

Amabile, N ;

Guérin, AP ;

Leroyer, A ;

Mallat, Z ;

Nguyen, C ;

Boddaert, J ;

London, GM ;

Tedgui, A ;

Boulanger, CM .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (11) :3381-3388

[5]

Global MicroRNA Profiling of the Mouse Ventricles during Development of Severe Hypertrophic Cardiomyopathy and Heart Failure [J].

Bagnall, Richard D. ;

Tsoutsman, Tatiana ;

Shephard, Rhian E. ;

Ritchie, William ;

Semsarian, Christopher .

PLOS ONE, 2012, 7 (09)

[6]

Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction [J].

Boulanger, CM ;

Scoazec, A ;

Ebrahimian, T ;

Henry, P ;

Mathieu, E ;

Tedgui, A ;

Mallat, Z .

CIRCULATION, 2001, 104 (22) :2649-2652

[7]

Role of stem-cell-derived microvesicles in the paracrine action of stem cells [J].

Camussi, Giovanni ;

Deregibus, Maria Chiara ;

Cantaluppi, Vincenzo .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2013, 41 :283-287

[8]

Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens [J].

Carmen Martinez, Maria ;

Larbret, Frederic ;

Zobairi, Fatiha ;

Coulombe, Josee ;

Debili, Najet ;

Vainchenker, William ;

Ruat, Martial ;

Freyssinet, Jean-Marie .

BLOOD, 2006, 108 (09) :3012-3020

[9]

Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury [J].

Chen, Lijuan ;

Wang, Yingjie ;

Pan, Yaohua ;

Zhang, Lan ;

Shen, Chengxing ;

Qin, Gangjian ;

Ashraf, Muhammad ;

Weintraub, Neal ;

Ma, Genshan ;

Tang, Yaoliang .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 431 (03) :566-571

[10]

Extracellular vesicles: biology and emerging therapeutic opportunities [J].

EL Andaloussi, Samir ;

Maeger, Imre ;

Breakefield, Xandra O. ;

Wood, Matthew J. A. .

NATURE REVIEWS DRUG DISCOVERY, 2013, 12 (05) :348-358

← 1 2 3 4 →