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Highly parallel genomic assays

被引：270
作者：
Fan, Jian-Bing
Chee, Mark S.
Gunderson, Kevin L.
机构：
[1] Illumina Inc, San Diego, CA 92121 USA
[2] Prognosys Biosci Inc, La Jolla, CA 92037 USA
来源：
NATURE REVIEWS GENETICS | 2006年 / 7卷 / 08期
关键词：
D O I：
10.1038/nrg1901
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Recent developments in highly parallel genome-wide assays are transforming the study of human health and disease. High-resolution whole-genome association studies of complex diseases are finally being undertaken after much hypothesizing about their merit for finding disease loci. The availability of inexpensive high-density SNP-genotyping arrays has made this feasible. Cancer biology will also be transformed by high-resolution genomic and epigenomic analysis. In the future, most cancers might be staged by high-resolution molecular profiling rather than by gross cytological analysis. Here, we describe the key developments that enable highly parallel genomic assays.
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页码：632 / 644
页数：13
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