Autophagy in healthy aging and disease

被引：959

作者：

Aman, Yahyah ^{[1
,2
,3
]}

Schmauck-Medina, Tomas ^{[1
,2
]}

Hansen, Malene ^{[4
]}

Morimoto, Richard, I ^{[5
]}

Simon, Anna Katharina ^{[6
]}

Bjedov, Ivana ^{[3
,7
]}

Palikaras, Konstantinos ^{[8
]}

Simonsen, Anne ^{[9
,10
,11
]}

Johansen, Terje ^{[12
]}

Tavernarakis, Nektarios ^{[13
,14
]}

Rubinsztein, David C. ^{[15
,16
]}

Partridge, Linda ^{[3
,17
]}

Kroemer, Guido ^{[18
,19
,20
,21
,22
]}

Labbadia, John ^{[3
]}

Fang, Evandro F. ^{[1
,2
,23
]}

机构：

[1] Univ Oslo, Dept Clin Mol Biol, Lorenskog, Norway

[2] Akershus Univ Hosp, Lorenskog, Norway

[3] UCL, Inst Hlth Ageing, Dept Genet Evolut & Environm, London, England

[4] Sanford Burnham Prebys Med Discovery Inst, Dev Aging & Regenerat Program, La Jolla, CA USA

[5] Northwestern Univ, Dept Mol Biosci, Rice Inst Biomed Res, Evanston, IL USA

[6] Univ Oxford, Kennedy Inst Rheumatol, Oxford, England

[7] UCL, UCL Canc Inst, London, England

[8] Natl & Kapodistrian Univ Athens, Sch Med, Dept Physiol, Athens, Greece

[9] Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Mol Med, Oslo, Norway

[10] Univ Oslo, Fac Med, Ctr Canc Cell Reprogramming, Inst Clin Med, Oslo, Norway

[11] Oslo Univ Hosp, Inst Canc Res, Dept Mol Cell Biol, Oslo, Norway

[12] Univ Tromso Arctic Univ Norway, Inst Med Biol, Mol Canc Res Grp, Tromso, Norway

[13] Fdn Res & Technol Hellas, Inst Mol Biol & Biotechnol, Iraklion, Greece

[14] Univ Crete, Sch Med, Dept Basic Sci, Iraklion, Greece

[15] Cambridge Inst Med Res, Dept Med Genet, Cambridge, England

[16] Univ Cambridge, UK Dementia Res Inst, Cambridge, England

[17] Max Planck Inst Biol Ageing, Dept Biol Mech Ageing, Cologne, Germany

[18] Univ Paris, Sorbonne Univ, INSERM U1138,Inst Univ France, Ctr Rech Cordeliers Equipe Labellisee Ligue Canc, Paris, France

[19] Gustave Roussy, Metabol & Cell Biol Platforms, Villejuif, France

[20] Hop Europeen Georges Pompidou, AP HP, Pole Biol, Paris, France

[21] Chinese Acad Med Sci, Suzhou Inst Syst Med, Suzhou, Peoples R China

[22] Karolinska Inst, Karolinska Univ Hosp, Dept Womens & Childrens Hlth, Stockholm, Sweden

[23] Norwegian Ctr Hlth Ageing NO Age, Oslo, Norway

来源：

NATURE AGING | 2021年 / 1卷 / 08期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 欧洲研究理事会; 欧盟地平线“2020”; 美国国家卫生研究院; 英国医学研究理事会; 中国国家自然科学基金;

关键词：

LIFE-SPAN EXTENSION; CHAPERONE-MEDIATED AUTOPHAGY; SELECTIVE AUTOPHAGY; MYCOBACTERIUM-TUBERCULOSIS; CAUSES NEURODEGENERATION; GLYCOGEN-METABOLISM; INDUCE AUTOPHAGY; LIPID-METABOLISM; C; ELEGANS; MITOCHONDRIAL;

D O I：

10.1038/s43587-021-00098-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

This Review synthesizes recent research on the mechanisms and roles of autophagy in health, aging and disease and discusses how drugs that modulate the process of autophagy could be used to suppress age-associated diseases. Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival. While autophagy is intimately linked to health, the intricate relationship among autophagy, aging and disease remains unclear. This Review examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease. In addition, we discuss current preclinical evidence arguing for the use of autophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases. Finally, we highlight key questions and propose novel research avenues that will likely reveal new links between autophagy and the hallmarks of aging. Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate the development of clinical applications that promote long-term health.

引用

页码：634 / 650

页数：17

共 246 条

[1]

Glycogen metabolism in humans [J].