Protective effects of bergenin, the major constituent of Mallotus japonicus, on D-galactosamine-intoxicated rat hepatocytes

被引：34

作者：

Lim, HK

Kim, HS ^{[1
]}

Chung, MW

Kim, YC

机构：

[1] Chungbuk Natl Univ, Coll Pharm, Dept Pharmacol, Cheongju 361763, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2000年 / 70卷 / 01期

关键词：

Mallotus japonicus; bergenin; galactosamine; hepatoprotective effects; primary cultured rat hepatocytes;

D O I：

10.1016/S0378-8741(99)00138-5

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

This study was designed to investigate the effects of bergenin against D-galactosamine-induced injury in primary cultured rat hepatocytes. Bergenin (100 mu M) decreased the release of glutamic pyruvic transaminase and sorbitol dehydrogenase by 62 and 50%, respectively, into hepatocyte medium incubated for 14 h with 1.5 mM galactosamine. Decreased RNA synthesis by 1.5 mM galactosamine was recovered 2.5 times compared with that of control hepatocytes at 100 mu M bergenin. Therefore, the present results suggest that bergenin show hepatoprotective effects against galactosamine-intoxicated rat hepatocytes by inhibiting the release of glutamic pyruvic transaminase and sorbitol dehydrogenase as well as by increasing RNA synthesis. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：69 / 72

页数：4

共 22 条

[1] EFFECTS OF BERGENIN ON EXPERIMENTAL ULCERS - PREVENTION OF STRESS-INDUCED ULCERS IN RATS [J].