Peptide deformylase of eukaryotic protists: A target for new antiparasitic agents?

被引：55

作者：

Meinnel, T ^{[1
]}

机构：

[1] CNRS, UPR40, Inst Sci Vegetales, F-91198 Gif Sur Yvette, France

来源：

PARASITOLOGY TODAY | 2000年 / 16卷 / 04期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

D O I：

10.1016/S0169-4758(99)01627-0

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Peptide deformylase is found only in Eubacteria, making it a logical target for discovering new antibacterial agents. Although this protein is absent from animal or fungal cells, evidence supports its existence in eukaryotic protists, including the causative agents of malaria, sleeping sickness, Chagas disease and leishmaniosis. Here, Thierry Meinnel discusses the idea that deformylase inhibitors could be used ns very broad-spectrum antibiotics against bacterial infections, as well as parasitic diseases.

引用

页码：165 / 168

页数：4

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